活性氧：益处、危害与谜团
Reactive oxygen species: The good, the bad, and the enigma.
作者信息
Ogrunc Müge
机构信息
IFOM Foundation - FIRC Institute of Molecular Oncology Foundation ; Milan, Italy.
出版信息
Mol Cell Oncol. 2014 Dec 23;1(3):e964033. doi: 10.4161/23723548.2014.964033. eCollection 2014 Jul-Sep.
Abstract
Work carried out primarily in the laboratory of Fabrizio d'Adda di Fagagna unveils the mitogenic properties of Ras-induced reactive oxygen species (ROS) and their relationship with the DNA damage response. Combined data from studies of cultured cells, zebrafish models, and clinical material consistently support a role of the RAS-RAC1-NOX4 axis in ROS induction, hyperproliferation, and senescence.
摘要
主要在法布里齐奥·达达·迪法加纳实验室开展的研究揭示了Ras诱导的活性氧（ROS）的促有丝分裂特性及其与DNA损伤反应的关系。来自培养细胞、斑马鱼模型和临床材料研究的综合数据一致支持RAS-RAC1-NOX4轴在ROS诱导、过度增殖和衰老中的作用。
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