静止期癌症干细胞的隐秘生活。
The secret life of quiescent cancer stem cells.
作者信息
Zeuner Ann
机构信息
Department of Hematology, Oncology and Molecular Medicine; Istituto Superiore di Sanità ; Rome, Italy.
出版信息
Mol Cell Oncol. 2014 Oct 30;2(1):e968067. doi: 10.4161/23723548.2014.968067. eCollection 2015 Jan-Mar.
Abstract
Quiescence represents a survival strategy adopted by cancer stem cells (CSCs) to resist harsh environmental conditions and cytotoxic insults. Recent studies show that quiescent CSCs are found in a low metabolic state in which they are exquisitely dependent on Bcl-2 or Bcl-XL, indicating new potential routes of clinical intervention.
摘要
静止状态是癌症干细胞（CSCs）采用的一种生存策略，用于抵抗恶劣的环境条件和细胞毒性损伤。最近的研究表明，静止的癌症干细胞处于低代谢状态，在这种状态下它们极度依赖Bcl-2或Bcl-XL，这表明了新的临床干预潜在途径。
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