Fernández-Martínez P, Zahonero C, Sánchez-Gómez P
Instituto de Medicina Molecular Aplicada; Universidad CEU-San Pablo ; Madrid, Spain.
Neuro-oncology Unit; Instituto de Salud Carlos III-UFIEC ; Madrid, Spain.
Mol Cell Oncol. 2015 Jan 30;2(1):e970048. doi: 10.4161/23723548.2014.970048. eCollection 2015 Jan-Mar.
DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications for embryonic development, especially in the nervous system where it regulates the balance between proliferation and differentiation of neural progenitors. The DYRK1A gene is located in the Down syndrome critical region and may play a significant role in the developmental brain defects, early neurodegeneration, and cancer susceptibility of individuals with this syndrome. DYRK1A is also expressed in adults, where it might participate in the regulation of cell cycle, survival, and tumorigenesis, thus representing a potential therapeutic target for certain types of cancer. However, the final readout of DYRK1A overexpression or inhibition depends strongly on the cellular context, as it has both tumor suppressor and oncogenic activities. Here, we will discuss the functions and substrates of DYRK1A associated with the control of cell growth and tumorigenesis with a focus on the potential use of DYRK1A inhibitors in cancer therapy.
双重特异性酪氨酸调节激酶1A（DYRK1A）是一种激酶，对胚胎发育具有多种影响，尤其是在神经系统中，它调节神经祖细胞增殖与分化之间的平衡。DYRK1A基因位于唐氏综合征关键区域，可能在该综合征患者的脑部发育缺陷、早期神经退行性变和癌症易感性中起重要作用。DYRK1A在成人中也有表达，可能参与细胞周期、存活和肿瘤发生的调节，因此是某些类型癌症的潜在治疗靶点。然而，DYRK1A过表达或抑制的最终结果在很大程度上取决于细胞环境，因为它兼具肿瘤抑制和致癌活性。在此，我们将讨论与细胞生长控制和肿瘤发生相关的DYRK1A的功能和底物，重点关注DYRK1A抑制剂在癌症治疗中的潜在应用。
