死亡，还是不死亡：在血清饥饿期间，E2F1 从不独自做出决定。
To die, or not to die: E2F1 never decides by itself during serum starvation.
作者信息
Sakamuro Daitoku, Folk Watson P, Kumari Alpana
机构信息
Department of Biochemistry and Molecular Biology; Medical College of Georgia; Georgia Regents University Cancer Center ; Augusta, GA USA.
出版信息
Mol Cell Oncol. 2015 Jan 7;2(2):e981447. doi: 10.4161/23723556.2014.981447. eCollection 2015 Apr-Jun.
Abstract
The adenovirus E2 promoter-binding factor-1 (E2F1) induces apoptosis in response to DNA damage and serum starvation. After DNA damage, E2F1 is phosphorylated by ataxia telangiectasia-mutated (ATM) kinase to promote apoptosis. However, precisely how serum starvation stimulates E2F1-induced apoptosis is unclear. We recently found that serum starvation reduces E2F1 poly(ADP-ribosyl)ation, thereby releasing a proapoptotic protein, bridging integrator-1 (BIN1), into the cytoplasm.
摘要
腺病毒E2启动子结合因子1（E2F1）在DNA损伤和血清饥饿反应中诱导细胞凋亡。DNA损伤后，E2F1被共济失调毛细血管扩张突变（ATM）激酶磷酸化以促进细胞凋亡。然而，血清饥饿如何精确刺激E2F1诱导的细胞凋亡尚不清楚。我们最近发现，血清饥饿会降低E2F1的多聚（ADP-核糖基）化，从而将一种促凋亡蛋白——桥联整合因子1（BIN1）释放到细胞质中。
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本文引用的文献
1
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Cell Death Differ. 2015 Feb;22(2):311-22. doi: 10.1038/cdd.2014.146. Epub 2014 Sep 26.
2
DNA damage signals through differentially modified E2F1 molecules to induce apoptosis.DNA 损伤通过差异修饰的 E2F1 分子发出信号，诱导细胞凋亡。
Mol Cell Biol. 2012 Mar;32(5):900-12. doi: 10.1128/MCB.06286-11. Epub 2011 Dec 19.
3
c-MYC suppresses BIN1 to release poly(ADP-ribose) polymerase 1: a mechanism by which cancer cells acquire cisplatin resistance.c-MYC 抑制 BIN1 释放聚（ADP-核糖）聚合酶 1：癌细胞获得顺铂耐药性的一种机制。
Sci Signal. 2011 Mar 29;4(166):ra19. doi: 10.1126/scisignal.2001556.
4
The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage.c-MYC 相互作用的促凋亡肿瘤抑制因子 BIN1 是 E2F1 在应对 DNA 损伤时的转录靶标。
Cell Death Differ. 2009 Dec;16(12):1641-53. doi: 10.1038/cdd.2009.98. Epub 2009 Jul 24.
5
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase.PARP-1独立于其DNA结合域和催化域与E2F-1结合，并在静止细胞重新进入S期期间作为E2F-1介导转录的新型共激活因子发挥作用。
Oncogene. 2003 Nov 20;22(52):8460-71. doi: 10.1038/sj.onc.1206897.
6
Chk2 activates E2F-1 in response to DNA damage.Chk2在DNA损伤时激活E2F-1。
Nat Cell Biol. 2003 May;5(5):401-9. doi: 10.1038/ncb974.
7
BIN1 is a novel MYC-interacting protein with features of a tumour suppressor.BIN1是一种具有肿瘤抑制因子特征的新型MYC相互作用蛋白。
Nat Genet. 1996 Sep;14(1):69-77. doi: 10.1038/ng0996-69.
8
E2F and cell proliferation: a world turned upside down.E2F与细胞增殖：天翻地覆的世界。
Cell. 1996 May 17;85(4):457-9. doi: 10.1016/s0092-8674(00)81244-1.
9
Binding and suppression of the Myc transcriptional activation domain by p107.
Science. 1994 Apr 8;264(5156):251-4. doi: 10.1126/science.8146655.
10
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Cell. 1991 Jun 14;65(6):1053-61. doi: 10.1016/0092-8674(91)90557-f.
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