有丝分裂-分化检查点，表皮基因组的另一个守护者。
The mitosis-differentiation checkpoint, another guardian of the epidermal genome.
作者信息
Gandarillas Alberto, Molinuevo Rut, Freije Ana, Alonso-Lecue Pilar
机构信息
Cell Cycle; Stem cell Fate and Cancer Laboratory; Instituto de Investigación Marqués de Valdecilla (IDIVAL); Santander, Spain; INSERM; Languedoc-Roussillon; Montpellier, France.
Cell Cycle; Stem cell Fate and Cancer Laboratory; Instituto de Investigación Marqués de Valdecilla (IDIVAL) ; Santander, Spain.
出版信息
Mol Cell Oncol. 2015 Jan 21;2(3):e997127. doi: 10.1080/23723556.2014.997127. eCollection 2015 Jul-Sep.
The role of p53, the original "guardian of the genome", in skin has remained elusive. We have explored p53 function in human epidermal cells and demonstrated the importance of a mitosis-differentiation checkpoint to suppress potentially precancerous cells. This model places epidermal endoreplication as an antioncogenic mechanism in the face of irreparable genetic alterations.
最初的“基因组守护者”p53在皮肤中的作用一直难以捉摸。我们已经探究了p53在人类表皮细胞中的功能，并证明了有丝分裂-分化检查点在抑制潜在癌前细胞方面的重要性。面对无法修复的基因改变，该模型将表皮内复制视为一种抗癌机制。
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