MKP1介导HER2阳性乳腺肿瘤的治疗耐药性。
MKP1 mediates resistance to therapy in HER2-positive breast tumors.
作者信息
Candas Demet, Li Jian Jian
机构信息
School of Medicine; Department of Radiation Oncology; NCI-designated Comprehensive Cancer Center; University of California Davis ; Sacramento, CA, USA.
出版信息
Mol Cell Oncol. 2015 Jan 23;2(4):e997518. doi: 10.1080/23723556.2014.997518. eCollection 2015 Oct-Dec.
Abstract
Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies.
摘要
丝裂原活化蛋白激酶磷酸酶1（MKP1或DUSP1）是一种抗凋亡磷酸酶，在包括乳腺癌在内的许多癌症中均有过表达。MKP1在接受放疗的乳腺癌细胞中可被诱导表达，且与人类表皮生长因子受体2（ERBB2，HER2）的表达相关。MKP1在治疗耐药性中的作用表明，在HER2阳性乳腺肿瘤中靶向作用于MKP1可能会显著提高抗HER2及其他抗癌疗法的疗效。
相似文献
1
MKP1 mediates resistance to therapy in HER2-positive breast tumors.MKP1介导HER2阳性乳腺肿瘤的治疗耐药性。
Mol Cell Oncol. 2015 Jan 23;2(4):e997518. doi: 10.1080/23723556.2014.997518. eCollection 2015 Oct-Dec.
2
Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells.线粒体双特异性磷酸酶1是耐治疗性HER2阳性乳腺癌细胞的一个靶点。
Cancer Res. 2014 Dec 15;74(24):7498-509. doi: 10.1158/0008-5472.CAN-14-0844. Epub 2014 Nov 6.
3
Mitogen-activated protein kinase phosphatase 1 is involved in tamoxifen resistance in MCF7 cells.丝裂原活化蛋白激酶磷酸酶1参与MCF7细胞对他莫昔芬的耐药性。
Oncol Rep. 2015 Nov;34(5):2423-30. doi: 10.3892/or.2015.4244. Epub 2015 Sep 2.
4
High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response.MKP1/DUSP1的高表达可抵消胶质瘤干细胞活性并介导HDAC抑制剂反应。
Oncogenesis. 2017 Dec 14;6(12):401. doi: 10.1038/s41389-017-0003-9.
5
MKP1 repression is required for the chemosensitizing effects of NF-kappaB and PI3K inhibitors to cisplatin in non-small cell lung cancer.MKP1 抑制是 NF-κB 和 PI3K 抑制剂增强非小细胞肺癌对顺铂化疗敏感性所必需的。
Cancer Lett. 2009 Dec 28;286(2):206-16. doi: 10.1016/j.canlet.2009.05.029. Epub 2009 Jun 23.
6
Light-inducible and clock-controlled expression of MAP kinase phosphatase 1 in mouse central pacemaker neurons.丝裂原活化蛋白激酶磷酸酶1在小鼠中枢起搏器神经元中的光诱导和时钟控制表达。
J Biol Rhythms. 2007 Apr;22(2):127-39. doi: 10.1177/0748730406298332.
7
Mitogen-activated protein kinase phosphatase 1 protects PC12 cells from amyloid beta-induced neurotoxicity.丝裂原活化蛋白激酶磷酸酶1保护PC12细胞免受β-淀粉样蛋白诱导的神经毒性。
Neural Regen Res. 2018 Oct;13(10):1842-1850. doi: 10.4103/1673-5374.238621.
8
Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells.人表皮生长因子受体2状态调节乳腺癌细胞中雌激素受体α的亚细胞定位及其相互作用。
Clin Cancer Res. 2004 Jun 1;10(11):3621-8. doi: 10.1158/1078-0432.CCR-0740-3.
9
Parathyroid hormone induces mitogen-activated kinase phosphatase 1 in murine osteoblasts primarily through cAMP-protein kinase A signaling.甲状旁腺激素主要通过环磷酸腺苷-蛋白激酶A信号传导途径诱导小鼠成骨细胞中的丝裂原活化蛋白激酶磷酸酶1。
J Periodontol. 2006 Jan;77(1):21-30. doi: 10.1902/jop.2006.77.1.21.
10
EPHA5 mediates trastuzumab resistance in HER2-positive breast cancers through regulating cancer stem cell-like properties.Epha5 通过调节癌症干细胞样特性介导曲妥珠单抗耐药的 HER2 阳性乳腺癌。
FASEB J. 2019 Apr;33(4):4851-4865. doi: 10.1096/fj.201701561RRRR. Epub 2019 Jan 8.
引用本文的文献
1
Resistance to Radiotherapy in Cancer.癌症对放疗的抗性
Diseases. 2025 Jan 17;13(1):22. doi: 10.3390/diseases13010022.
2
Low let-7d microRNA levels in chick embryos enhance innate immunity against Mycoplasma gallisepticum by suppressing the mitogen-activated protein kinase pathway.鸡胚中低水平的 let-7d 微 RNA 通过抑制丝裂原活化蛋白激酶途径增强了对鸡毒支原体的固有免疫。
Vet Res. 2023 Jun 19;54(1):50. doi: 10.1186/s13567-023-01178-6.
3
Long Noncoding RNA SNHG4 Attenuates the Injury of Myocardial Infarction via Regulating miR-148b-3p/DUSP1 Axis.长链非编码 RNA SNHG4 通过调控 miR-148b-3p/DUSP1 轴减轻心肌梗死损伤。
Cardiovasc Ther. 2022 Dec 5;2022:1652315. doi: 10.1155/2022/1652315. eCollection 2022.
4
Downregulation of tripartite motif protein 11 attenuates cardiomyocyte apoptosis after ischemia/reperfusion injury via DUSP1-JNK1/2.三结构域蛋白 11 的下调通过 DUSP1-JNK1/2 减轻缺血/再灌注损伤后的心肌细胞凋亡。
Cell Biol Int. 2022 Jan;46(1):148-157. doi: 10.1002/cbin.11716. Epub 2021 Nov 10.
5
HER2-positive breast cancer that resists therapeutic drugs and ionizing radiation releases sphingomyelin-based molecules to circulating blood serum.对治疗药物和电离辐射产生抗性的HER2阳性乳腺癌会向循环血清中释放基于鞘磷脂的分子。
Mol Clin Oncol. 2020 Dec;13(6):70. doi: 10.3892/mco.2020.2140. Epub 2020 Sep 21.
6
Elevated HDAC activity and altered histone phospho-acetylation confer acquired radio-resistant phenotype to breast cancer cells.组蛋白去乙酰化酶活性升高和组蛋白磷酸化乙酰化改变赋予乳腺癌细胞获得性放射抵抗表型。
Clin Epigenetics. 2020 Jan 3;12(1):4. doi: 10.1186/s13148-019-0800-4.
7
DUSP1 induces apatinib resistance by activating the MAPK pathway in gastric cancer.DUSP1 通过激活 MAPK 通路诱导胃癌对阿帕替尼耐药。
Oncol Rep. 2018 Sep;40(3):1203-1222. doi: 10.3892/or.2018.6520. Epub 2018 Jun 25.
8
DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways.DUSP1 通过抑制 JNK 通路调控的 Mff 依赖性线粒体分裂和 Bnip3 相关的线粒体自噬来减轻心脏缺血/再灌注损伤。
Redox Biol. 2018 Apr;14:576-587. doi: 10.1016/j.redox.2017.11.004. Epub 2017 Nov 6.
本文引用的文献
1
Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells.线粒体双特异性磷酸酶1是耐治疗性HER2阳性乳腺癌细胞的一个靶点。
Cancer Res. 2014 Dec 15;74(24):7498-509. doi: 10.1158/0008-5472.CAN-14-0844. Epub 2014 Nov 6.
2
HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells.从 HER2 阴性乳腺癌细胞中分离的乳腺癌干细胞的 HER2 相关放射抵抗性。
Clin Cancer Res. 2012 Dec 15;18(24):6634-47. doi: 10.1158/1078-0432.CCR-12-1436. Epub 2012 Oct 22.
3
Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer.丝裂原活化蛋白（MAP）激酶/ MAP激酶磷酸酶调控：在细胞生长、死亡及癌症中的作用
Pharmacol Rev. 2008 Sep;60(3):261-310. doi: 10.1124/pr.107.00106.
4
Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-kappaB regulation.丝裂原活化蛋白激酶磷酸酶-1通过核因子κB调控抑制c-Jun氨基末端激酶介导的细胞凋亡。
J Biol Chem. 2008 Jul 25;283(30):21011-23. doi: 10.1074/jbc.M802229200. Epub 2008 May 27.
5
Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer.丝裂原活化蛋白激酶磷酸酶MKP1、MKP2在人乳腺癌中的过表达。
Cancer Lett. 2003 Mar 10;191(2):229-37. doi: 10.1016/s0304-3835(02)00612-2.
6
The biology of human epidermal growth factor receptor 2.人类表皮生长因子受体2的生物学特性
Curr Oncol Rep. 1999 Sep;1(1):16-22. doi: 10.1007/s11912-999-0005-7.
7
Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage.应激激活蛋白激酶/应激活化蛋白激酶（SAPK/JNK）转位至线粒体并在DNA损伤反应中与Bcl-x(L)相互作用。
J Biol Chem. 2000 Jan 7;275(1):322-7. doi: 10.1074/jbc.275.1.322.
Zotero 插件