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ATF3在前列腺癌抑制中的新作用。

Emerging roles of ATF3 in the suppression of prostate cancer.

作者信息

Wang Ziyan, Yan Chunhong

机构信息

GRU Cancer Center.

GRU Cancer Center; Department of Biochemistry and Molecular Biology; Medical College of Georgia; Georgia Regents University; Augusta, GA USA.

出版信息

Mol Cell Oncol. 2015 Feb 3;3(1):e1010948. doi: 10.1080/23723556.2015.1010948. eCollection 2016 Jan.

DOI:10.1080/23723556.2015.1010948
PMID:27308526
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4845162/
Abstract

Stress response mediator activating transcription factor 3 (ATF3) engages in diverse oncogenic pathways including the androgen receptor signaling essential for prostatic proliferation. In line with frequent downregulation of ATF3 expression in human prostate cancers, we have provided the first genetic evidence supporting the role of ATF3 as a tumor suppressor in a subset of prostate cancers with PTEN dysfunction.

摘要

应激反应介质激活转录因子3（ATF3）参与多种致癌途径，包括对前列腺增殖至关重要的雄激素受体信号传导。鉴于ATF3在人类前列腺癌中经常下调，我们提供了首个遗传学证据，支持ATF3在一部分具有PTEN功能障碍的前列腺癌中作为肿瘤抑制因子的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ce/4845162/c2915985223e/kmco-03-01-1010948-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ce/4845162/c2915985223e/kmco-03-01-1010948-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00ce/4845162/c2915985223e/kmco-03-01-1010948-g001.jpg

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2
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