辐射诱导的c-MYC扩增会引发乳腺癌发生吗？
Does radiation-induced c-MYC amplification initiate breast oncogenesis?
作者信息
Wade Mark A, May Felicity E B, Onel Ken, Allan James M
机构信息
Northern Institute for Cancer Research; Newcastle University ; Newcastle upon Tyne, UK.
Department of Pediatrics; University of Chicago ; Chicago, IL USA.
出版信息
Mol Cell Oncol. 2015 Feb 3;3(1):e1010950. doi: 10.1080/23723556.2015.1010950. eCollection 2016 Jan-Feb.
Abstract
The MYC (v-myc avian myelocytomatosis viral oncogene homolog; c-MYC) locus on chromosome 8q is susceptible to high-level amplification following exposure of human breast cells to ionizing radiation, and c-MYC amplification is a common feature of both radiogenic adenocarcinoma and radiogenic angiosarcoma of the breast. Taken together, these observations suggest common breast-specific susceptibility factors that predispose cells to amplification of this critical proto-oncogene and the development of radiogenic cancer in multiple tissue types of this radiosensitive organ.
摘要
位于8号染色体q臂上的MYC（v-myc禽骨髓细胞瘤病毒癌基因同源物；c-MYC）基因座，在人乳腺细胞受到电离辐射后易发生高水平扩增，而c-MYC扩增是乳腺放射性腺癌和放射性血管肉瘤的共同特征。综合这些观察结果表明，存在常见的乳腺特异性易感因素，使细胞易于扩增这一关键原癌基因，并在这个放射敏感器官的多种组织类型中引发放射性癌症。
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