mTORC1在自噬中的作用扩展。
An expanded role for mTORC1 in autophagy.
作者信息
Kim Young-Mi, Park Ji-Man, Grunwald Douglas, Kim Do-Hyung
机构信息
Department of Biochemistry; Molecular Biology, and Biophysics; University of Minnesota ; Minneapolis, MN USA.
Department of Biochemistry; Molecular Biology, and Biophysics; University of Minnesota; Minneapolis, MN USA; Masonic Cancer Center; University of Minnesota; Minneapolis, MN USA.
出版信息
Mol Cell Oncol. 2015 Feb 3;3(1):e1010958. doi: 10.1080/23723556.2015.1010958. eCollection 2016 Jan.
Mechanistic target of rapamycin complex 1 (mTORC1) negatively regulates autophagy at early stages by phosphorylating Unc51-like kinase 1 (ULK1). Our recent study expanded the roles of mTORC1 in autophagy by identifying ultraviolet radiation resistance-associated gene product (UVRAG) as a substrate of mTORC1. This finding has provided new insight into the roles of mTORC1 in cellular membrane processes and cancer.
雷帕霉素复合物1（mTORC1）的机制性靶点通过磷酸化Unc51样激酶1（ULK1）在早期对自噬进行负调控。我们最近的研究通过将紫外线抗性相关基因产物（UVRAG）鉴定为mTORC1的底物，扩展了mTORC1在自噬中的作用。这一发现为mTORC1在细胞膜过程和癌症中的作用提供了新的见解。
Zotero 插件