肝癌干细胞可能起源于成年导管祖细胞。
Hepatic cancer stem cells may arise from adult ductal progenitors.
作者信息
Nikolaou Kostas C, Talianidis Iannis
机构信息
Biomedical Sciences Research Center Al. Fleming ; Vari, Greece.
出版信息
Mol Cell Oncol. 2015 Mar 19;3(1):e1021946. doi: 10.1080/23723556.2015.1021946. eCollection 2016 Jan-Feb.
Abstract
Cancer stem cells (CSCs) are defined as cells within tumors that can self-renew and differentiate into heterogeneous lineages of cancerous cells. The origin of CSCs is not well understood. Recent evidence suggests that CSCs in hepatocellular carcinoma could be generated via oncogenic transformation and partial differentiation of adult hepatic ductal progenitor cells.
摘要
癌症干细胞（CSCs）被定义为肿瘤内能够自我更新并分化为异质性癌细胞谱系的细胞。癌症干细胞的起源尚未完全明确。最近的证据表明，肝细胞癌中的癌症干细胞可能是通过成人肝导管祖细胞的致癌转化和部分分化产生的。
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