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通过雌激素受体阳性（ER+）乳腺癌中干扰素调节因子1（IRF1）信号通路将自噬与炎症联系起来。

Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer.

作者信息

Cook Katherine L, Schwartz-Roberts Jessica L, Baumann William T, Clarke Robert

机构信息

Department of Oncology and Lombardi Comprehensive Cancer Center; Georgetown University Medical Center, Washington, DC USA; Department of Surgery, Hypertension and Vascular Research Center, Wake Forest Comprehensive Cancer Center; Wake Forest University, Winston-Salem, NC USA.

Department of Oncology and Lombardi Comprehensive Cancer Center; Georgetown University Medical Center , Washington, DC USA.

出版信息

Mol Cell Oncol. 2015 Apr 14;3(1):e1023928. doi: 10.1080/23723556.2015.1023928. eCollection 2016 Jan.

DOI:10.1080/23723556.2015.1023928
PMID:27308537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4845173/
Abstract

Resistance to antiestrogen therapy remains a critical determinant of mortality in patients affected by ER+ breast cancer. Our previous work identified autophagy and interferon regulatory factor 1 (IRF1) signaling as key regulators of this process. We have recently demonstrated a novel reciprocal interaction between IRF1 and ATG7, linking inflammation and autophagy.

摘要

抗雌激素治疗耐药仍然是雌激素受体阳性（ER+）乳腺癌患者死亡率的关键决定因素。我们之前的研究确定自噬和干扰素调节因子1（IRF1）信号传导是这一过程的关键调节因子。我们最近证明了IRF1与自噬相关基因7（ATG7）之间存在一种新的相互作用，将炎症与自噬联系起来。

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本文引用的文献

1
Interferon regulatory factor-1 signaling regulates the switch between autophagy and apoptosis to determine breast cancer cell fate.干扰素调节因子-1信号传导调节自噬与凋亡之间的转换，以决定乳腺癌细胞的命运。
Cancer Res. 2015 Mar 15;75(6):1046-55. doi: 10.1158/0008-5472.CAN-14-1851. Epub 2015 Jan 9.
2
Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer.羟氯喹啉抑制自噬以增强雌激素受体阳性乳腺癌的抗雌激素反应性。
Clin Cancer Res. 2014 Jun 15;20(12):3222-32. doi: 10.1158/1078-0432.CCR-13-3227.
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Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.葡萄糖调节蛋白 78 控制细胞凋亡和自噬之间的串扰，以决定抗雌激素反应性。
Cancer Res. 2012 Jul 1;72(13):3337-49. doi: 10.1158/0008-5472.CAN-12-0269.
5
Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate.内质网应激、未折叠蛋白反应、自噬和乳腺癌细胞命运的综合调控。
Cancer Res. 2012 Mar 15;72(6):1321-31. doi: 10.1158/0008-5472.CAN-11-3213.
6
The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer.干扰素调节因子-1（IRF1）在克服乳腺癌治疗中抗雌激素耐药性方面的作用。
Int J Breast Cancer. 2011;2011:912102. doi: 10.4061/2011/912102. Epub 2011 Jul 3.
7
Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a proapoptotic unfolded protein response.硼替佐米通过增强雌激素受体的聚集来增强氟维司群的疗效，从而导致促凋亡的未折叠蛋白反应。
Clin Cancer Res. 2011 Apr 15;17(8):2292-300. doi: 10.1158/1078-0432.CCR-10-1745. Epub 2011 Feb 3.
8
International Web-based consultation on priorities for translational breast cancer research.基于网络的国际乳腺癌转化研究优先事项咨询会
Breast Cancer Res. 2007;9(6):R81. doi: 10.1186/bcr1798.
9
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Oncogene. 2004 Nov 18;23(54):8743-55. doi: 10.1038/sj.onc.1208120.
10
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Oncogene. 2004 Feb 5;23(5):1125-35. doi: 10.1038/sj.onc.1207023.