核糖体蛋白中的突变：细胞凋亡、细胞竞争与癌症。
Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer.
作者信息
Baker Nicholas E, Kale Abhijit
机构信息
Department of Genetics; Albert Einstein College of Medicine; Bronx, NY USA; Department of Developmental and Molecular Biology; Albert Einstein College of Medicine; Bronx, NY USA; Department of Ophthalmology and Visual Science; Albert Einstein College of Medicine; Bronx, NY USA.
Department of Genetics; Albert Einstein College of Medicine ; Bronx, NY USA.
出版信息
Mol Cell Oncol. 2015 May 7;3(1):e1029065. doi: 10.1080/23723556.2015.1029065. eCollection 2016 Jan.
Abstract
Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/+ heterozygous cells, or Rp/+ heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.
摘要
影响多种核糖体蛋白的突变与癌症有关。利用果蝇中的基因嵌合体，我们描述了3种凋亡机制，这些机制影响Rp/Rp纯合突变细胞、Rp/+杂合细胞，或与附近野生型细胞竞争的Rp/+杂合细胞，并讨论了细胞凋亡可能与癌症易感性之间的关系。
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