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核糖体蛋白中的突变：细胞凋亡、细胞竞争与癌症。

Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer.

作者信息

Baker Nicholas E, Kale Abhijit

机构信息

Department of Genetics; Albert Einstein College of Medicine; Bronx, NY USA; Department of Developmental and Molecular Biology; Albert Einstein College of Medicine; Bronx, NY USA; Department of Ophthalmology and Visual Science; Albert Einstein College of Medicine; Bronx, NY USA.

Department of Genetics; Albert Einstein College of Medicine ; Bronx, NY USA.

出版信息

Mol Cell Oncol. 2015 May 7;3(1):e1029065. doi: 10.1080/23723556.2015.1029065. eCollection 2016 Jan.

DOI:10.1080/23723556.2015.1029065
PMID:27308545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4845181/
Abstract

Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/+ heterozygous cells, or Rp/+ heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.

摘要

影响多种核糖体蛋白的突变与癌症有关。利用果蝇中的基因嵌合体，我们描述了3种凋亡机制，这些机制影响Rp/Rp纯合突变细胞、Rp/+杂合细胞，或与附近野生型细胞竞争的Rp/+杂合细胞，并讨论了细胞凋亡可能与癌症易感性之间的关系。

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本文引用的文献

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Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica.核糖体蛋白突变细胞竞争过程中的凋亡机制：起始半胱天冬酶Dronc和Dream/Strica的作用
Cell Death Differ. 2015 Aug;22(8):1300-12. doi: 10.1038/cdd.2014.218. Epub 2015 Jan 23.
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An ancient defense system eliminates unfit cells from developing tissues during cell competition.在细胞竞争过程中，一种古老的防御系统会从发育组织中清除功能失调的细胞。
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