核糖体蛋白中的突变：细胞凋亡、细胞竞争与癌症。
Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer.
作者信息
Baker Nicholas E, Kale Abhijit
机构信息
Department of Genetics; Albert Einstein College of Medicine; Bronx, NY USA; Department of Developmental and Molecular Biology; Albert Einstein College of Medicine; Bronx, NY USA; Department of Ophthalmology and Visual Science; Albert Einstein College of Medicine; Bronx, NY USA.
Department of Genetics; Albert Einstein College of Medicine ; Bronx, NY USA.
出版信息
Mol Cell Oncol. 2015 May 7;3(1):e1029065. doi: 10.1080/23723556.2015.1029065. eCollection 2016 Jan.
Abstract
Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/+ heterozygous cells, or Rp/+ heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.
摘要
影响多种核糖体蛋白的突变与癌症有关。利用果蝇中的基因嵌合体，我们描述了3种凋亡机制，这些机制影响Rp/Rp纯合突变细胞、Rp/+杂合细胞，或与附近野生型细胞竞争的Rp/+杂合细胞，并讨论了细胞凋亡可能与癌症易感性之间的关系。
相似文献
1
Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer.
Mol Cell Oncol. 2015 May 7;3(1):e1029065. doi: 10.1080/23723556.2015.1029065. eCollection 2016 Jan.
2
Ribosomal protein mutations and cell competition: autonomous and nonautonomous effects on a stress response.
Genetics. 2023 Jul 6;224(3). doi: 10.1093/genetics/iyad080.
3
Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica.
Cell Death Differ. 2015 Aug;22(8):1300-12. doi: 10.1038/cdd.2014.218. Epub 2015 Jan 23.
4
A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition.
Dev Cell. 2018 Aug 20;46(4):456-469.e4. doi: 10.1016/j.devcel.2018.07.003. Epub 2018 Aug 2.
5
Ribosomal Protein S12e Has a Distinct Function in Cell Competition.
Dev Cell. 2018 Jan 8;44(1):42-55.e4. doi: 10.1016/j.devcel.2017.12.007.
6
Genes affecting cell competition in Drosophila.
Genetics. 2007 Feb;175(2):643-57. doi: 10.1534/genetics.106.061929. Epub 2006 Nov 16.
7
Silencing the Drosophila ribosomal protein L14 gene using targeted RNA interference causes distinct somatic anomalies.
Gene. 2003 Nov 27;320:41-8. doi: 10.1016/s0378-1119(03)00827-8.
8
Emerging mechanisms of cell competition.
Nat Rev Genet. 2020 Nov;21(11):683-697. doi: 10.1038/s41576-020-0262-8. Epub 2020 Aug 10.
9
The developmental basis for germline mosaicism in mouse and Drosophila melanogaster.
Genetica. 1998;102-103(1-6):421-43.
10
Somatic clones heterozygous for recessive disease alleles of exhibit unexpected phenotypes in .
Elife. 2018 May 10;7:e35258. doi: 10.7554/eLife.35258.
引用本文的文献
1
Stemming Tumoral Growth: A Matter of Grotesque Organogenesis.
Cells. 2023 Mar 11;12(6):872. doi: 10.3390/cells12060872.
2
Early Onset Colorectal Cancer: An Emerging Cancer Risk in Patients with Diamond Blackfan Anemia.
Genes (Basel). 2021 Dec 26;13(1):56. doi: 10.3390/genes13010056.
3
Comparative proteomics reveals mechanisms that underlie insecticide resistance in Culex pipiens pallens Coquillett.
PLoS Negl Trop Dis. 2021 Mar 25;15(3):e0009237. doi: 10.1371/journal.pntd.0009237. eCollection 2021 Mar.
4
Ribosomal Protein S12e Has a Distinct Function in Cell Competition.
Dev Cell. 2018 Jan 8;44(1):42-55.e4. doi: 10.1016/j.devcel.2017.12.007.
5
Mechanisms of cell competition emerging from Drosophila studies.
Curr Opin Cell Biol. 2017 Oct;48:40-46. doi: 10.1016/j.ceb.2017.05.002. Epub 2017 Jun 7.
6
Transcriptome and long noncoding RNA sequencing of three extracellular vesicle subtypes released from the human colon cancer LIM1863 cell line.
Sci Rep. 2016 Dec 5;6:38397. doi: 10.1038/srep38397.
7
Comparative proteomics analysis of Spodoptera frugiperda cells during Autographa californica multiple nucleopolyhedrovirus infection.
Virol J. 2015 Aug 4;12:115. doi: 10.1186/s12985-015-0346-9.
本文引用的文献
1
Apoptotic mechanisms during competition of ribosomal protein mutant cells: roles of the initiator caspases Dronc and Dream/Strica.
Cell Death Differ. 2015 Aug;22(8):1300-12. doi: 10.1038/cdd.2014.218. Epub 2015 Jan 23.
2
An ancient defense system eliminates unfit cells from developing tissues during cell competition.
Science. 2014 Dec 5;346(6214):1258236. doi: 10.1126/science.1258236.
3
Germline mutation of RPS20, encoding a ribosomal protein, causes predisposition to hereditary nonpolyposis colorectal carcinoma without DNA mismatch repair deficiency.
Gastroenterology. 2014 Sep;147(3):595-598.e5. doi: 10.1053/j.gastro.2014.06.009. Epub 2014 Jun 15.
4
Cell competition: how to eliminate your neighbours.
Development. 2014 Mar;141(5):988-1000. doi: 10.1242/dev.079129.
5
Myc-driven endogenous cell competition in the early mammalian embryo.
Nature. 2013 Aug 1;500(7460):39-44. doi: 10.1038/nature12389. Epub 2013 Jul 10.
6
Apoptosome structure, assembly, and procaspase activation.
Structure. 2013 Apr 2;21(4):501-15. doi: 10.1016/j.str.2013.02.024.
7
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.
Nat Genet. 2013 Feb;45(2):186-90. doi: 10.1038/ng.2508. Epub 2012 Dec 23.
8
Diamond Blackfan anemia: a disorder of red blood cell development.
Curr Top Dev Biol. 2008;82:217-41. doi: 10.1016/S0070-2153(07)00008-7.
9
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen.
Nature. 2008 Jan 17;451(7176):335-9. doi: 10.1038/nature06494.
10
Cell proliferation in carcinogenesis.
Science. 1990 Aug 31;249(4972):1007-11. doi: 10.1126/science.2204108.
Zotero 插件