RIPK1的双重作用
The double life of RIPK1.
作者信息
Jin Lei, Chen Jiezhong, Liu Xiao Ying, Jiang Chen Chen, Zhang Xu Dong
机构信息
School of Medicine and Public Health, The University of Newcastle , NSW, Australia.
School of Biomedical Sciences and Pharmacy, The University of Newcastle , NSW, Australia.
出版信息
Mol Cell Oncol. 2015 May 26;3(1):e1035690. doi: 10.1080/23723556.2015.1035690. eCollection 2016 Jan.
Abstract
We have recently identified receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1) as an oncogenic driver in melanoma in addition to its well-established role in controlling cell survival and death. Our studies show that RIPK1 promotes melanoma cell proliferation through a positive feedback loop of NFKB1-BIRC2/BIRC3-RIPK1 powered by autocrine tumor necrosis factor.
摘要
我们最近发现，受体（TNFRSF）相互作用丝氨酸 - 苏氨酸激酶1（RIPK1）除了在控制细胞存活和死亡方面已确立的作用外，还是黑色素瘤的致癌驱动因素。我们的研究表明，RIPK1通过由自分泌肿瘤坏死因子驱动的NFKB1 - BIRC2 / BIRC3 - RIPK1正反馈回路促进黑色素瘤细胞增殖。
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