Zlatanou Anastasia, Stewart Grant S
School of Cancer Sciences, University of Birmingham , Birmingham, UK.
Mol Cell Oncol. 2015 Jul 6;3(1):e1063571. doi: 10.1080/23723556.2015.1063571. eCollection 2016 Jan.
RAD18 functions to promote DNA damage tolerance (DTT), a process that ensures faithful genome duplication. Protein ubiquitylation/deubiquitylation is a critical regulatory mechanism controlling DTT. Recently, we have identified the deubiquitylating enzyme USP7 as a component of the DTT machinery that acts to protect RAD18 from proteasome-dependent degradation.
RAD18的功能是促进DNA损伤耐受（DTT），这是一个确保基因组忠实复制的过程。蛋白质泛素化/去泛素化是控制DTT的关键调节机制。最近，我们鉴定出去泛素化酶USP7是DTT机制的一个组成部分，其作用是保护RAD18免受蛋白酶体依赖性降解。
