Di Virgilio Francesco
Department of Morphology; Surgery and Experimental Medicine; Section of Pathology; Oncology and Experimental Biology; University of Ferrara ; Ferrara, Italy.
Mol Cell Oncol. 2015 Feb 3;3(2):e1010937. doi: 10.1080/23723556.2015.1010937. eCollection 2016 Mar.
P2X7 (also known as P2RX7) is a plasma membrane receptor for extracellular ATP that is expressed at a high level by immune and tumor cells. Previous data showed that increased P2rx7 expression by tumor cells accelerates tumor progression. We have now looked at the other side of the relationship by investigating the effect of a lack of host P2rx7 expression on tumor growth. Our novel observations highlight a surprising role of host P2rx7 in restraining tumor progression.
P2X7（也称为P2RX7）是一种细胞外ATP的质膜受体，在免疫细胞和肿瘤细胞中高水平表达。先前的数据表明，肿瘤细胞中P2rx7表达增加会加速肿瘤进展。我们现在通过研究宿主缺乏P2rx7表达对肿瘤生长的影响，来审视这种关系的另一面。我们的新发现突出了宿主P2rx7在抑制肿瘤进展中令人惊讶的作用。
