微小RNA——从转移预测到转移预防？
MicroRNAs-from metastasis prediction to metastasis prevention?
作者信息
Abba Mohammed, Patil Nitin, Leupold Jörg Hendrik, Allgayer Heike
机构信息
Department of Experimental Surgery, Medical Faculty Mannheim, Theodor Kutzer Ufer 1-3, 68135 Mannheim, Ruprecht Karl University of Heidelberg, Germany; Centre for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Ludolf-Krehl-Str. 6, 68135 Mannheim, Ruprecht Karl University of Heidelberg, Germany.
出版信息
Mol Cell Oncol. 2015 Dec 10;3(2):e1074336. doi: 10.1080/23723556.2015.1074336. eCollection 2016 Mar.
Abstract
Recently, we suggested the microRNA (miR) landscape defining metastasis. The first miR-driven network orchestrating invasion, intravasation, and metastasis was confirmed independently across several malignancies, suggesting a rather general principle for metastasis regulation. We hope that our data will stimulate the field in terms of further hypothesis generation, metastasis prediction, and metastasis prevention.
摘要
最近，我们提出了定义转移的微小RNA（miR）格局。首个由miR驱动的协调侵袭、血管内渗和转移的网络在多种恶性肿瘤中得到了独立验证，这表明转移调控存在一个相当普遍的原则。我们希望我们的数据能在进一步提出假设、转移预测和转移预防方面推动该领域的发展。
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