Namba H, Iwasa H, Kubota M, Yamaura A, Sato T, Hagihara Y, Makino H
Department of Neurosurgery, Chiba University School of Medicine, Japan.
Brain Res. 1989 May 8;486(2):221-7. doi: 10.1016/0006-8993(89)90508-8.
Local cerebral glucose utilization was measured by means of the quantitative autoradiographic 2-[14C]deoxyglucose method during the postictal phase of various seizure stages of amygdaloid kindling in conscious rats. The partially kindled animals exhibited a partial seizure such as chewing and/or head nodding, and the fully kindled animals, a generalized tonic-clonic convulsion. The control animals were implanted with an electrode, but not electrically stimulated. Cerebral glucose utilization of the fully kindled animals was deeply depressed in the postictal phase as compared to the control, and that of the partially kindled animals was moderately decreased. The side-to-side differences of cerebral glucose utilization were observed only in the partially kindled group in which glucose utilization was more depressed on the side of stimulation. Among the structures with depressed glucose utilization, only one structure, the interpeduncular nucleus, showed a relative increase in glucose utilization during the postictal phase of the kindled groups. As the postictal phase has been considered as a period of inhibition, these results may indicate that the neural networks linking the interpeduncular nucleus play an active role in the mechanisms of termination of a seizure and postictal refractoriness.
采用定量放射自显影2-[14C]脱氧葡萄糖法，在清醒大鼠杏仁核点燃不同发作阶段的发作后期，测量局部脑葡萄糖利用率。部分点燃的动物表现出如咀嚼和/或点头等部分性发作，而完全点燃的动物则出现全身性强直阵挛性惊厥。对照动物植入了电极，但未进行电刺激。与对照组相比，完全点燃动物在发作后期的脑葡萄糖利用率显著降低，部分点燃动物的脑葡萄糖利用率则中度降低。仅在部分点燃组观察到脑葡萄糖利用率的左右差异，其中刺激侧的葡萄糖利用率降低更为明显。在葡萄糖利用率降低的结构中，只有一个结构，即脚间核，在点燃组的发作后期显示出葡萄糖利用率相对增加。由于发作后期被认为是一个抑制期，这些结果可能表明，连接脚间核的神经网络在癫痫发作终止和发作后不应期机制中发挥着积极作用。
