Gandaglia Giorgio, Montorsi Francesco, Montorsi Piero
U.O. Urologia, Divisione di Oncologia, IRCCS Ospedale San Raffaele, Milano e Università Vita-Salute San Raffaele, Milano.
U.O. Cardiologia, Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi, Centro Cardiologico Monzino, IRCCS, Milano.
G Ital Cardiol (Rome). 2016 May;17(5):356-62. doi: 10.1714/2252.24262.
Erectile dysfunction (ED) is common among patients with cardiovascular diseases (CVD). Sexual problems usually precede the onset of CVD and should, therefore, be considered as a risk factor for cardiac events. Similarly, patients with preexisting CVD are at increased risk of experiencing ED. Therefore, ED and CVD might be considered as two different clinical manifestations of the same systemic disease. Moreover, these conditions share many common pathophysiological mechanisms. Patients with preexisting CVD and ED should be stratified according to their cardiovascular risk. Sexual activity is safe in patients at low risk of CVD and these individuals might be treated with pro-erectile medications. On the other hand, men at high risk of CVD should be reassessed and the cardiac condition should be stabilized before they might have sexual attempts. Recent evidence suggests that lifestyle changes, administration of phosphodiesterase type-5 inhibitors, and testosterone supplementation might improve sexual function and reduce the risk of experiencing CVD during follow-up.
勃起功能障碍(ED)在心血管疾病(CVD)患者中很常见。性问题通常先于CVD发作,因此应被视为心脏事件的危险因素。同样,已有CVD的患者发生ED的风险增加。因此,ED和CVD可能被视为同一全身性疾病的两种不同临床表现。此外,这些病症有许多共同的病理生理机制。已有CVD和ED的患者应根据其心血管风险进行分层。对于CVD低风险患者,性活动是安全的,这些个体可以使用促勃起药物治疗。另一方面,CVD高风险男性应重新评估,在尝试性行为之前应先稳定心脏状况。最近的证据表明,生活方式改变、给予5型磷酸二酯酶抑制剂和补充睾酮可能改善性功能,并降低随访期间发生CVD的风险。