Liu Hong-Yan, Gu Wei-Jun, Wang Cheng-Zhi, Ji Xiao-Jian, Mu Yi-Ming
Department of Endocrinology Department of rheumatology, Chinese PLA General Hospital, Haidian District, Beijing, P.R. China.
Medicine (Baltimore). 2016 Jun;95(24):e3904. doi: 10.1097/MD.0000000000003904.
The extracellular matrix is important for tumor invasion and metastasis. Normal function of the extracellular matrix depends on the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). The objective of this meta-analysis was to assess the relationship between expression of MMP-9, MMP-2, and TIMP-2 and invasion of pituitary adenomas.We searched Pubmed, Embase, and the Chinese Biomedical Database up to October 2015. RevMan 5.1 software (Cochrane Collaboration, Copenhagen, Denmark) was used for statistical analysis. We calculated the standardized mean difference (SMD) for data expressed as mean ± standard deviation because of the difference in the detection method.Twenty-four studies (1320 patients) were included. MMP-9 expression was higher in the patients with invasive pituitary adenomas (IPAs) than patients with noninvasive pituitary adenomas (NIPAs) with detection methods of IHC [odds ratio (OR) = 5.48, 95% confidence interval (CI) = 2.61-11.50, P < 0.00001), and reverse transcriptase-polymerase chain reaction (SMD = 2.28, 95% CI = 0.91-3.64, P = 0.001). MMP-2 expression was also increased in patients with IPAs at the protein level (OR = 3.58, 95% CI = 1.63-7.87, P = 0.001), and RNA level (SMD = 3.91, 95% CI = 1.52-6.29, P = 0.001). Meta-analysis showed that there was no difference in TIMP-2 expression between invasive and NIPAs at the protein level (OR = 0.38, 95% CI = 0.06-2.26, P = 0.29). MMP-9 expression in prolactinomas and nonfunctioning pituitary adenomas was also no difference (OR = 1.03, 95% CI = 0.48-2.20, P = 0.95).The results indicated that MMP-9 and -2 may be correlated with invasiveness of pituitary adenomas, although their relationship with functional status of pituitary adenomas is still not clear. TIMP-2 expression in IPAs needs to be investigated further.
细胞外基质对肿瘤侵袭和转移至关重要。细胞外基质的正常功能取决于基质金属蛋白酶（MMPs）和金属蛋白酶组织抑制剂（TIMPs）之间的平衡。本荟萃分析的目的是评估MMP - 9、MMP - 2和TIMP - 2的表达与垂体腺瘤侵袭之间的关系。我们检索了截至2015年10月的PubMed、Embase和中国生物医学数据库。使用RevMan 5.1软件（丹麦哥本哈根的Cochrane协作网）进行统计分析。由于检测方法的差异，我们对以均值±标准差表示的数据计算标准化均数差（SMD）。纳入了24项研究（1320例患者）。采用免疫组化检测方法时，侵袭性垂体腺瘤（IPA）患者的MMP - 9表达高于非侵袭性垂体腺瘤（NIPA）患者[比值比（OR）= 5.48，95%置信区间（CI）= 2.61 - 11.50，P < 0.00001]，采用逆转录聚合酶链反应时（SMD = 2.28，95% CI = 0.91 - 3.64，P = 0.001）。IPA患者在蛋白质水平（OR = 3.58，95% CI = 1.63 - 7.87，P = 0.001）和RNA水平（SMD = 3.91，95% CI = 1.52 - 6.29，P = 0.001）的MMP - 2表达也增加。荟萃分析显示，侵袭性和非侵袭性垂体腺瘤在蛋白质水平的TIMP - 2表达无差异（OR = 0.38，95% CI = 0.06 - 2.26，P = 0.29）。催乳素瘤和无功能垂体腺瘤中的MMP - 9表达也无差异（OR = 1.03，95% CI = 0.48 - 2.20，P = 0.95）。结果表明，MMP - 9和 - 2可能与垂体腺瘤的侵袭性相关，尽管它们与垂体腺瘤功能状态的关系仍不明确。IPA中TIMP - 2的表达需要进一步研究。
