Burton Julien, Worth Andrew P, Tsakovska Ivanka, Diukendjieva Antonia
Systems Toxicology Unit and EURL ECVAM, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, Ispra, Varese, Italy.
Department of QSAR & Molecular Modeling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Methods Mol Biol. 2016;1425:177-200. doi: 10.1007/978-1-4939-3609-0_10.
In this chapter, we give an overview of the regulatory requirements for acute systemic toxicity information in the European Union, and we review the availability of structure-based computational models that are available and potentially useful in the assessment of acute systemic toxicity. The most recently published literature models for acute systemic toxicity are also discussed, and perspectives for future developments in this field are offered.
在本章中，我们概述了欧盟对急性全身毒性信息的监管要求，并回顾了基于结构的计算模型的可用性，这些模型在急性全身毒性评估中是可用的且可能有用。我们还讨论了最近发表的急性全身毒性文献模型，并提供了该领域未来发展的展望。
