Tien H F, Chuang S M, Wang C H, Lee F Y, Chien S H, Chen Y C, Shen M C, Liu C H
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.
Cancer Genet Cytogenet. 1989 May;39(1):89-97. doi: 10.1016/0165-4608(89)90234-3.
Cytogenetic study was performed in the past 3 years on 23 Chinese patients with Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) in transformation; seven were in accelerated phase and 16 in acute blast crisis. Chromosomal abnormalities in addition to Ph were found in three (43%) of the patients at accelerated phase and 14 (88%) of the patients at blast crisis. The common nonrandom chromosomal aberrations were double Ph, trisomy 8, trisomy 19, and trisomy 21, which occurred in 47%, 41%, 35%, and 29%, respectively, of the total patients with extra chromosomal abnormalities. Isochromosome for the long arm of chromosome 17 was found in only one patient. In patients with blast crisis, the type of blast cell was characterized through morphologic, cytochemical, and immunocytochemical studies. Eleven cases were classified as myeloid and five as lymphoid transformation. Trisomy 8, 19, and 21 were detected only in patients with myeloid blast crisis. This study also revealed a high incidence of trisomy 21 and a low incidence of i(17q) in Chinese patients with transformation of CML.
在过去3年中，对23例处于转化期的费城染色体（Ph）阳性慢性粒细胞白血病（CML）中国患者进行了细胞遗传学研究；其中7例处于加速期，16例处于急性原始细胞危象期。处于加速期的患者中有3例（43%）以及处于原始细胞危象期的患者中有14例（88%）发现了除Ph之外的染色体异常。常见的非随机染色体畸变有双Ph、三体8、三体19和三体21，分别发生在有额外染色体异常的全部患者中的47%、41%、35%和29%。仅1例患者发现了17号染色体长臂等臂染色体。对于处于原始细胞危象期的患者，通过形态学、细胞化学和免疫细胞化学研究对原始细胞类型进行了鉴定。11例被归类为髓系转化，5例为淋巴系转化。三体8、19和21仅在髓系原始细胞危象患者中检测到。本研究还显示，中国CML转化患者中三体21的发生率较高，而i(17q)的发生率较低。
