Griesshammer M, Heinze B, Bangerter M, Heimpel H, Fliedner T M
Department of Internal Medicine III, University of Ulm, Germany.
J Mol Med (Berl). 1997 Nov-Dec;75(11-12):836-8. doi: 10.1007/s001090050173.
We examined karyotypes and their prognostic significance in a series of 122 patients with chronic myeloid leukemia in blast crisis. Of 73 patients cytogenetically examined at the onset of blast crisis 63% had developed secondary cytogenetic abnormalities in addition to the Philadelphia chromosome. These newly emerging abnormalities included a double Philadelphia chromosome in 20 patients, a trisomy 8 in 17, and an isochromosome 17q in 11 patients. Development of such additional karyotypic abnormalities was significantly associated with a shorter median survival and less response to cytoreductive treatment and was significantly more common in nonlymphoid blast crisis than in the lymphoid-type blast crisis. Thus, assessment of karyotypes at the onset of chronic myeloid leukemia blast crisis appears to be of prognostic significance for both remission duration and survival.
我们在122例慢性髓性白血病急变期患者中研究了核型及其预后意义。在73例于急变期开始时进行细胞遗传学检查的患者中，63%除费城染色体外还出现了继发性细胞遗传学异常。这些新出现的异常包括20例患者有双费城染色体、17例有8号染色体三体以及11例有17号染色体长臂等臂染色体。出现此类额外的核型异常与较短的中位生存期及对细胞减灭治疗的反应较差显著相关，并且在非淋巴细胞性急变期比淋巴细胞性急变期更常见。因此，慢性髓性白血病急变期开始时的核型评估对于缓解期持续时间和生存期似乎都具有预后意义。
