Song G G, Lee Y H
Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, 02841, Seoul, Korea.
Z Rheumatol. 2017 Apr;76(3):267-273. doi: 10.1007/s00393-016-0093-3.
The aim of the present study was to determine whether polymorphisms of the endothelial nitric oxide synthase (eNOS) gene are associated with susceptibility to osteonecrosis of the femoral head (ONFH).
We conducted a meta-analysis to assess the association between the 4b/a, G894T, and T786C polymorphisms of eNOS and the susceptibility to ONFH.
A total of five studies, which included 566 cases and 833 controls, were included in the meta-analysis. Meta-analysis revealed a significant association between allele a of the 4b/a polymorphism and ONFH in all study subjects (odds ratio, OR 3.237; 95 % confidence interval, CI 2.036-5.148; P = 6.9 × 10); stratification by ethnicity indicated an association between this allele and ONFH in Caucasians and Asians (OR 2.985; 95 % CI 1.592-5.597; P = 0.001 and OR 3.567; 95 % CI 1.793-7.095; P = 2.9 × 10, respectively). Meta-analysis stratified by ONFH type showed a significant association between allele a of the 4b/a polymorphism and idiopathic and secondary ONFH (OR 3.411; 95 % CI 2.049-5.679; P = 2.4 × 10 and OR 3.163; 95 % CI 1.781-5.619, P = 8.6 × 10 , respectively). However, the meta-analysis did not show any allelic association between the G894T and T786C polymorphisms and ONFH (OR 1.718; 95 % CI 0.796-3.707; P = 0.168 and OR 1.027; 95 % CI 0.191-5.517; P = 0.976, respectively).
Our meta-analysis of published studies shows that the 4b/a polymorphism is associated with the development of idiopathic and secondary ONFH in Caucasians and Asians.
本研究旨在确定内皮型一氧化氮合酶（eNOS）基因多态性是否与股骨头坏死（ONFH）易感性相关。
我们进行了一项荟萃分析，以评估eNOS基因的4b/a、G894T和T786C多态性与ONFH易感性之间的关联。
荟萃分析共纳入五项研究，包括566例病例和833例对照。荟萃分析显示，在所有研究对象中，4b/a多态性的a等位基因与ONFH之间存在显著关联（比值比，OR 3.237；95%置信区间，CI 2.036 - 5.148；P = 6.9×10）；按种族分层表明，该等位基因与白种人和亚洲人的ONFH相关（OR 2.985；95% CI 1.592 - 5.597；P = 0.001和OR 3.567；95% CI 1.793 - 7.095；P = 2.9×10）。按ONFH类型分层的荟萃分析显示，4b/a多态性的a等位基因与特发性和继发性ONFH之间存在显著关联（OR 3.411；95% CI 2.049 - 5.679；P = 2.4×10和OR 3.163；95% CI 1.781 - 5.619，P = 8.6×10）。然而，荟萃分析未显示G894T和T786C多态性与ONFH之间存在任何等位基因关联（OR 1.718；95% CI 0.796 - 3.707；P = 0.168和OR 1.027；95% CI 0.191 - 5.517；P = 0.976）。
我们对已发表研究的荟萃分析表明，4b/a多态性与白种人和亚洲人的特发性和继发性ONFH的发生相关。
