Zhou Z C, Gu S Z, Wu J, Liang Q W
Department of Orthopedics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
Department of Orthopedics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
Genet Mol Res. 2015 Oct 29;14(4):13688-98. doi: 10.4238/2015.October.28.31.
We investigated the associations between vascular endothelial growth factors (VEGF), endothelial nitric oxide synthase (eNOS), and ATP-binding cassette subfamily B member 1 transporter (ABCB1) polymorphisms and the risk of osteonecrosis of the femoral head (ONFH). Published studies were reviewed and analyzed based on predefined selection criteria. The strength of the association between VEGF, eNOS, and ABCB1 polymorphisms and ONFH risk was evaluated based on the odds ratio with corresponding 95%CIs. Meta-analysis was performed using the Comprehensive Meta-analysis 2.0 software. A total of 135 relevant articles were retrieved, of which 10 studies met the selection criteria, and included a total of 1025 patients with ONFH and 1730 healthy controls. The meta-analysis study results revealed that the VEGF rs2010963 G>C polymorphism increased the risk of ONFH, while the VEGF rs2010963 G>C and ABCB1 rs1045642 C>T polymorphisms increased the risk of ONFH under the allele model. In conclusion, the VEGF, eNOS, and ABCB1 polymorphisms may contribute to ONFH, but further studies including larger sample sizes are needed to confirm the results.
我们研究了血管内皮生长因子（VEGF）、内皮型一氧化氮合酶（eNOS）和ATP结合盒转运体B家族成员1（ABCB1）基因多态性与股骨头坏死（ONFH）风险之间的关联。根据预先设定的选择标准对已发表的研究进行综述和分析。基于比值比及其相应的95%置信区间评估VEGF、eNOS和ABCB1基因多态性与ONFH风险之间关联的强度。使用Comprehensive Meta-analysis 2.0软件进行荟萃分析。共检索到135篇相关文章，其中10项研究符合选择标准，共纳入1025例ONFH患者和1730例健康对照。荟萃分析研究结果显示，VEGF rs2010963 G>C多态性增加了ONFH的风险，而在等位基因模型下，VEGF rs2010963 G>C和ABCB1 rs1045642 C>T多态性增加了ONFH的风险。总之，VEGF、eNOS和ABCB1基因多态性可能与ONFH有关，但需要包括更大样本量的进一步研究来证实这些结果。
