Zupančič Tina, Ponikvar Rafael, Gubenšek Jakob, Buturović-Ponikvar Jadranka
Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Faculty of Medicine, University of Ljubljana, Slovenia.
Ther Apher Dial. 2016 Jun;20(3):267-71. doi: 10.1111/1744-9987.12435.
The aim of our prospective study was to quantify phosphate removal during long nocturnal high-flux hemodialysis or hemodiafiltration (HD) with total dialysate collection. Eight patients (two women) were studied for the first-in-the-week HD session that lasted 7-8 h. Total dialysate was collected. Serum and collected dialysate phosphate concentrations were measured every hour. Phosphate removal as assessed from the serum concentration was most important during the first 2 h of HD, and then a plateau was reached. The highest average phosphate concentration in the total dialysate was in the 1(st) hour, thereafter the concentration decreased but remained stable. The average total removed mass of phosphate quantified from hourly collected dialysate was 5195.7 ± 1898 mg. Phosphate had been removed in a consistent manner during the whole duration of nocturnal HD as assessed through dialysate (despite stable serum phosphate concentration). This could indicate phosphate transfer from intracellular space. The total removed phosphate quantified from the total dialysate collection was higher than previously reported and exceeded the normal phosphate food intake.
我们前瞻性研究的目的是通过收集全部透析液，对长时间夜间高通量血液透析或血液透析滤过（HD）过程中的磷酸盐清除情况进行量化。对8名患者（2名女性）进行了本周首次持续7 - 8小时的HD治疗。收集全部透析液。每小时测量血清和收集的透析液中的磷酸盐浓度。从血清浓度评估的磷酸盐清除在HD的前2小时最为重要，随后达到平台期。全部透析液中最高的平均磷酸盐浓度在第1小时，此后浓度下降但保持稳定。从每小时收集的透析液中量化的平均总磷酸盐清除量为5195.7±1898毫克。通过透析液评估，在夜间HD的整个过程中磷酸盐一直以一致的方式被清除（尽管血清磷酸盐浓度稳定）。这可能表明磷酸盐从细胞内空间转移。从全部透析液收集中量化的总清除磷酸盐量高于先前报道，且超过了正常的磷酸盐食物摄入量。
