Koo Hyeon-Kyoung, Hong Yoonki, Lim Myoung Nam, Yim Jae-Joon, Kim Woo Jin
Department of Internal Medicine, Division of Pulmonary and Critical Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon-si, Republic of Korea.
Int J Chron Obstruct Pulmon Dis. 2016 May 27;11:1129-37. doi: 10.2147/COPD.S103281. eCollection 2016.
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation in the airway and lung. A protease-antiprotease imbalance has been suggested as a possible pathogenic mechanism for COPD. We evaluated the relationship between matrix metalloproteinase (MMP) levels and COPD severity.
Plasma levels of MMP-1, MMP-8, MMP-9, and MMP-12 were measured in 57 COPD patients and 36 normal controls. The relationship between MMP levels and lung function, emphysema index, bronchial wall thickness, pulmonary artery pressure, and quality of life was examined using general linear regression analyses.
There were significant associations of MMP-1 with bronchodilator reversibility and of MMP-8 and MMP-9 with lung function. Also, MMP-1, MMP-8, and MMP-9 levels were correlated with the emphysema index, independent of lung function. However, MMP-12 was not associated with lung function or emphysema severity. Associations between MMP levels and bronchial wall thickness, pulmonary artery pressure, and quality of life were not statistically significant.
Plasma levels of MMP-1, MMP-8, and MMP-9 are associated with COPD severity and can be used as a biomarker to better understand the characteristics of COPD patients.
慢性阻塞性肺疾病（COPD）的特征是气道和肺部的慢性炎症。蛋白酶-抗蛋白酶失衡被认为是COPD可能的致病机制。我们评估了基质金属蛋白酶（MMP）水平与COPD严重程度之间的关系。
测定了57例COPD患者和36例正常对照者血浆中MMP-1、MMP-8、MMP-9和MMP-12的水平。使用一般线性回归分析检查MMP水平与肺功能、肺气肿指数、支气管壁厚度、肺动脉压和生活质量之间的关系。
MMP-1与支气管扩张剂可逆性、MMP-8和MMP-9与肺功能之间存在显著关联。此外，MMP-1、MMP-8和MMP-9水平与肺气肿指数相关，与肺功能无关。然而，MMP-12与肺功能或肺气肿严重程度无关。MMP水平与支气管壁厚度、肺动脉压和生活质量之间的关联无统计学意义。
血浆中MMP-1、MMP-8和MMP-9水平与COPD严重程度相关，可作为生物标志物以更好地了解COPD患者的特征。
