生物量烟雾暴露导致 COPD 患者 FEV1 与基质金属蛋白酶 1、7、9 和 CRP 呈负相关。
FEV1 inversely correlates with metalloproteinases 1, 7, 9 and CRP in COPD by biomass smoke exposure.
机构信息
Departamento de Fibrosis Pulmonar, Calzada de Tlalpan 4502, Tlalpan D,F, México, C,P, 14080 México, DF, Mexico.
出版信息
Respir Res. 2014 Jun 30;15(1):74. doi: 10.1186/1465-9921-15-74.
BACKGROUND
Matrix metalloproteinases (MMPs) and C-reactive protein (CRP) are involved in chronic obstructive pulmonary disease (COPD) pathogenesis. The aim of the present work was to determine plasma concentrations of MMPs and CRP in COPD associated to biomass combustion exposure (BE) and tobacco smoking (TS).
METHODS
Pulmonary function tests, plasma levels of MMP-1, MMP-7, MMP-9, MMP-9/TIMP-1 and CRP were measured in COPD associated to BE (n = 40) and TS (n =40) patients, and healthy non-smoking (NS) healthy women (controls, n = 40).
RESULTS
Plasma levels of MMP-1, MMP-7, MMP-9, and MMP-9/TIMP-1 and CRP were higher in BE and TS than in the NS healthy women (p <0.01). An inverse correlation between MMP-1, MMP-7, MMP-9, MMP-9/TIMP-1 and CRP plasma concentrations and FEV1 was observed.
CONCLUSIONS
Increase of MMPs and CRP plasma concentrations in BE suggests a systemic inflammatory phenomenon similar to that observed in COPD associated to tobacco smoking, which may also play a role in COPD pathogenesis.
背景
基质金属蛋白酶（MMPs）和 C 反应蛋白（CRP）参与慢性阻塞性肺疾病（COPD）的发病机制。本研究的目的是确定与生物质燃烧暴露（BE）和吸烟（TS）相关的 COPD 患者的血浆 MMPs 和 CRP 浓度。
方法
测量了与 BE（n=40）和 TS（n=40）相关的 COPD 患者以及健康不吸烟（NS）的健康女性（对照组，n=40）的肺功能测试、血浆 MMP-1、MMP-7、MMP-9、MMP-9/TIMP-1 和 CRP 水平。
结果
与 NS 健康女性相比，BE 和 TS 患者的血浆 MMP-1、MMP-7、MMP-9 和 MMP-9/TIMP-1 以及 CRP 水平更高（p<0.01）。观察到 MMP-1、MMP-7、MMP-9、MMP-9/TIMP-1 和 CRP 血浆浓度与 FEV1 之间呈负相关。
结论
BE 中 MMPs 和 CRP 血浆浓度的增加表明存在类似于与吸烟相关的 COPD 中观察到的全身性炎症现象，这也可能在 COPD 的发病机制中发挥作用。
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