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喀麦隆透析患者特定心血管疾病风险因素的频率:贫血、炎症、磷酸盐和钙的情况

Frequency of Specific Cardiovascular Disease Risk Factors among Cameroonian Patients on Dialysis: The Cases of Anaemia, Inflammation, Phosphate, and Calcium.

作者信息

Pancha Mbouemboue Olivier, Danbe Olivier Djile, Tangyi Tamanji Marcel, Ngoufack Jacques Olivier

机构信息

Department of Biomedical Sciences, Faculty of Science, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon; General Medicine Service, Ngaoundéré Regional Hospital, P.O. Box 45, Ngaoundéré, Cameroon.

Department of Biomedical Sciences, Faculty of Science, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon.

出版信息

Cardiol Res Pract. 2016;2016:5031927. doi: 10.1155/2016/5031927. Epub 2016 May 22.

Abstract

Specific cardiovascular risk factors are known to contribute to increasing cardiovascular mortality in patients with chronic renal disease. However, little is known about their distribution in our population. This study aimed at determining the prevalence of anaemia, inflammation, and phosphocalcium disorders in Cameroonian patients on dialysis. Thirty-five participants with stage V chronic kidney disease (defined by glomerular filtration rate, GFR < 15 mL/1.73 m(3)) of age at least 20 years on haemodialysis were randomly recruited. A control group composed of persons without a history of renal or cardiovascular disease was also recruited. Haemoglobin concentration, serum phosphate concentration, serum calcium concentration, and CRP status as a marker of inflammation were determined for all participants. Anaemia, phosphocalcium metabolic disorders, and a positive CRP result among haemodialysed patients were estimated at 94.3%, 61.6%, and 77.1%, respectively. Anaemia was diagnosed in all female patients compared to 92% in males, while a positive CRP result was recorded in 90% of females and 72% of males. No significant differences were observed on the distribution of studied specific cardiovascular risk factors with duration of dialysis. Among the factors studied, anaemia was the most encountered.

摘要

已知特定的心血管危险因素会导致慢性肾病患者的心血管死亡率上升。然而,我们对这些危险因素在我国人群中的分布情况知之甚少。本研究旨在确定喀麦隆透析患者中贫血、炎症和磷钙紊乱的患病率。随机招募了35名年龄至少20岁、患有Ⅴ期慢性肾病(根据肾小球滤过率,GFR<15 mL/1.73 m²定义)且正在接受血液透析的参与者。还招募了一个由无肾脏或心血管疾病病史的人组成的对照组。测定了所有参与者的血红蛋白浓度、血清磷酸盐浓度、血清钙浓度以及作为炎症标志物的CRP状态。血液透析患者中的贫血、磷钙代谢紊乱和CRP结果呈阳性的比例分别估计为94.3%、61.6%和77.1%。所有女性患者均被诊断为贫血,男性患者的这一比例为92%,而女性患者中有90%的CRP结果呈阳性,男性患者中这一比例为72%。在所研究的特定心血管危险因素的分布方面,未观察到与透析时间存在显著差异。在所研究的因素中,贫血最为常见。

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Pathophysiology of anemia in chronic kidney diseases: A review.慢性肾脏病贫血的病理生理学:综述
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PLoS One. 2014 Jan 2;9(1):e84943. doi: 10.1371/journal.pone.0084943. eCollection 2014.
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Anemia in renal disease: diagnosis and management.肾脏疾病相关贫血:诊断与管理。
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