Afshar Reza, Sanavi Suzan, Salimi Javad, Ahmadzadeh Mahnaz
Nephrology Department, Shahed University, Mustafa Khomeini Hospital, Tehran, Iran.
Saudi J Kidney Dis Transpl. 2010 Mar;21(2):368-71.
Anemia is a common sequealae of chronic kidney disease (CKD), associated with significant morbidity. A cross-sectional study was conducted on 100 CKD patients (54 hemodialyzed, 46 pre-dialyzed). Data including, complete blood count, BUN, creatinine, creatinine clearance, underlying diseases and hemodialysis duration were collected by a questionnaire. The most frequent morphologic features were normochromic-normocytic (80%), hypochromic-microcytic (15%) and macrocytic (5%). The frequency of anemia in hemodialyzed and pre-dialyzed patients (with mean Hgb level of 10.27 and 11.11 g/dL) were 85% and 75%. Hemoglobin concentration was positively correlated to calculated creatinine clearance (P < 0.001). The severity of anemia among hemodialyzed patients was mild (Hgb > 10 g/dL) in 5%, moderate in 70% and severe (Hgb < 7 g/dL) in 25%, while in pre-dialyzed was mild in 45% and moderate in 55%. There was no correlation between the anemia and CKD causes or hemodialysis duration. In conclusion, data shows that anemia in our patients with CKD is a predominant manifestation, with high frequency but of moderate degree. The most likely cause is inadequate erythropoietin production.
贫血是慢性肾脏病（CKD）常见的后遗症，与显著的发病率相关。对100例CKD患者（54例接受血液透析，46例未透析）进行了一项横断面研究。通过问卷调查收集包括全血细胞计数、血尿素氮、肌酐、肌酐清除率、基础疾病和血液透析时间等数据。最常见的形态学特征为正色素正细胞性（80%）、低色素小细胞性（15%）和大细胞性（5%）。血液透析患者和未透析患者贫血的发生率（平均血红蛋白水平分别为10.27 g/dL和11.11 g/dL）分别为85%和75%。血红蛋白浓度与计算的肌酐清除率呈正相关（P < 0.001）。血液透析患者中，5%的患者贫血程度为轻度（血红蛋白>10 g/dL），70%为中度，25%为重度（血红蛋白<7 g/dL）；而未透析患者中，45%为轻度，55%为中度。贫血与CKD病因或血液透析时间无关。总之，数据表明，我们的CKD患者贫血是主要表现，发生率高但程度中等。最可能的原因是促红细胞生成素产生不足。
