十字路口的交叉点：1型神经纤维瘤病、环磷酸腺苷、性别与胶质瘤风险。
Intersections at the crossroads: Neurofibromatosis type 1, cAMP, sex, and glioma risk.
作者信息
Rubin Joshua B
机构信息
Department of Pediatrics, Anatomy and Neurobiology, Washington University School of Medicine , St Louis, MO.
出版信息
Mol Cell Oncol. 2015 Aug 3;3(3):e1069917. doi: 10.1080/23723556.2015.1069917. eCollection 2016 May.
Abstract
Cancer predisposition syndromes, particularly neurofibromatosis type 1 (NF1), provide unique vantage points from which to examine the co-contributions of molecular, cellular, and tissue processes to tumor biology. Polymorphisms in adenylate cyclase 8 affect brain tumor risk in NF1 in a sex-specific fashion, illuminating novel interdependencies in brain tumorigenesis.
摘要
癌症易感综合征，尤其是1型神经纤维瘤病（NF1），为研究分子、细胞和组织过程对肿瘤生物学的共同作用提供了独特的视角。腺苷酸环化酶8的多态性以性别特异性方式影响NF1患者患脑肿瘤的风险，揭示了脑肿瘤发生过程中全新的相互依存关系。
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