新型双（Ⅲ）异羟肟酸配合物：合成、脲酶抑制活性及抗幽门螺杆菌活性

Novel class of Bi(iii) hydroxamato complexes: synthesis, urease inhibitory activity and activity against H. pylori.

作者信息

Keogan D M, Twamley B, Fitzgerald-Hughes D, Griffith D M

机构信息

Centre for Synthesis & Chemical Biology, Department of Pharmaceutical & Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland.

School of Chemistry, Chemistry Building, Trinity College Dublin, Dublin 2, Ireland.

出版信息

Dalton Trans. 2016 Jul 5;45(27):11008-14. doi: 10.1039/c5dt05061h.

DOI:10.1039/c5dt05061h

PMID:27314129

Abstract

Reaction of Bi(NO3)3 with benzohydroxamic acid (Bha) and salicylhydroxamic acid (Sha) gives the novel Bi(iii) complexes [Bi2(Bha-1H)2(μ-Bha-1H)2(η(2)-NO3)2] () and Bi6(CH3OH)2(η(1)-NO3)2(η(2)-NO3)(OH2)2(Sha-1H)122 (). X-ray crystal structure of reveals two hydroxamato coordination modes; bidentate bridging (O, O') and bidentate non-bridging (O, O') and of reveals one coordination mode; bidentate bridging (O, O'). , specifically designed to and demonstrated to inhibit the activity of urease, exhibits excellent antibacterial activity against three strains of Helicobacter pylori with MIC ≥ 16 μg mL(-1).

摘要

硝酸铋（Bi(NO3)3）与苯甲酰氧肟酸（Bha）和水杨酰氧肟酸（Sha）反应生成了新型的Bi(iii)配合物[Bi2(Bha-1H)2(μ-Bha-1H)2(η(2)-NO3)2]（）和Bi6(CH3OH)2(η(1)-NO3)2(η(2)-NO3)(OH2)2(Sha-1H)122（）。的X射线晶体结构显示出两种异羟肟酸配位模式；双齿桥连（O，O'）和双齿非桥连（O，O'），而的则显示出一种配位模式；双齿桥连（O，O'）。专门设计用于并证明可抑制脲酶活性，对三株幽门螺杆菌表现出优异的抗菌活性，MIC≥16μg mL(-1)。