Department of Chemistry, Chung-Ang University , 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea.
Department of Bionanotechnology, Hanyang University , Ansan 15588, Republic of Korea.
Org Lett. 2016 Jul 1;18(13):3246-9. doi: 10.1021/acs.orglett.6b01495. Epub 2016 Jun 17.
Visible-light-induced arylthiofluoroalkylations of unactivated heteroaromatics and alkenes have been developed utilizing readily available arylthiofluoroalkyl sources. This method enables simultaneous installation of sulfur and fluoroalkyl moieties, two important functional groups, which demonstrates its potential use for late-stage modifications in the synthesis of functional molecules. This method can be easily utilized to fine-tune the properties of lead molecules in drug development by controlling the number of fluorine atoms in the reagents.
可见光诱导的未活化杂芳环和烯烃的芳基硫氟烷基化反应已经得到了发展，利用易得的芳基硫氟烷基源。该方法可以同时引入硫和氟烷基两种重要的官能团，展示了其在功能分子合成后期修饰中的潜在应用。该方法可以通过控制试剂中氟原子的数量，轻松地用于精细调整药物开发中先导分子的性质。
