Saga Yutaka, Nakayama Yusuke, Watanabe Taito, Kondo Mio, Masaoka Shigeyuki
Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Innovative Catalysis Science Division, Institute for Open and Transdisciplinary Research Initiatives (ICS-OTRI), Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Org Lett. 2023 Feb 24;25(7):1136-1141. doi: 10.1021/acs.orglett.2c04337. Epub 2023 Feb 15.
Herein, we report visible-light-driven hydroacylation of unactivated alkenes. We employed benzimidazolines as new acyl donors and achieved perfect regioselectivity, high functional-group tolerance, and excellent substrate generality. We also performed mechanistic experiments to elucidate the detailed reaction mechanism. This is the first example of (1) hydroacylation of unactivated alkenes using (2) easily prepared acyl donors under (3) visible-light irradiation. Our findings offer a new strategy to synthesize a wide variety of ketones under mild conditions.
在此，我们报道了未活化烯烃的可见光驱动氢酰化反应。我们使用苯并咪唑啉作为新型酰基供体，实现了完美的区域选择性、高官能团耐受性和出色的底物通用性。我们还进行了机理实验以阐明详细的反应机理。这是首例（1）在可见光照射下利用（2）易于制备的酰基供体对未活化烯烃进行氢酰化反应的实例。我们的研究结果为在温和条件下合成多种酮类化合物提供了一种新策略。
