美国国立精神卫生研究所情感障碍家族研究的描述。

Description of the National Institute of Mental Health family study of affective disorders.

作者信息

Gershon E S, Goldin L R, Guroff J J, Hamovit J R

机构信息

Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, MD 20892.

出版信息

Genet Epidemiol. 1989;6(1):183-5. doi: 10.1002/gepi.1370060132.

DOI:10.1002/gepi.1370060132

PMID:2731706

Abstract

The NIMH family study consisted of 172 probands with affective disorder and 43 normal control probands. Psychiatric disorders were diagnosed in relatives over the age of 18 using Research Diagnostic Criteria based on personal interviews, medical records, and family history information. Some families were also genotyped for red cell, serum, and HLA marker loci. Previous analyses of these data have shown that affective disorders aggregate in families. Segregation analyses have not been able to define the mode of inheritance.

摘要

美国国立精神卫生研究所的家族研究包括172名患有情感障碍的先证者和43名正常对照先证者。使用基于个人访谈、病历和家族病史信息的研究诊断标准，对18岁以上亲属的精神疾病进行诊断。一些家庭还对红细胞、血清和HLA标记位点进行了基因分型。此前对这些数据的分析表明，情感障碍在家族中具有聚集性。分离分析尚未能够确定其遗传模式。