使用逻辑模型对双相情感障碍进行家族分析。

Familial analysis of bipolar affective disorder using logistic models.

作者信息

Blangero J, Elston R C

机构信息

Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78284.

出版信息

Genet Epidemiol. 1989;6(1):221-7. doi: 10.1002/gepi.1370060139.

DOI:10.1002/gepi.1370060139

PMID:2731709

Abstract

Data on bipolar affective disorder in 187 pedigrees from the Collaborative Depression Study were analyzed using logistic models that have been extended to incorporate age of onset information. Logistic regression analysis and segregation analysis revealed evidence for complex familial effects on this disorder.

摘要

利用已扩展以纳入发病年龄信息的逻辑模型，对来自合作抑郁症研究的187个家系中的双相情感障碍数据进行了分析。逻辑回归分析和分离分析揭示了该疾病存在复杂家族效应的证据。