Bharti Ruchi, Parvin Tasneem
Department of Chemistry, National Institute of Technology Patna, Ashok Rajpath, Patna, 800005, India.
Mol Divers. 2016 Nov;20(4):867-876. doi: 10.1007/s11030-016-9681-z. Epub 2016 Jun 17.
A series of pyrano-fused benzophenazines were synthesized using a bifunctional thiourea-based organocatalyst from the one-pot four-component reaction of 2-hydroxy-1,4-naphthoquinone, benzene-1,2-diamines, malononitrile or its derivatives and isatins or aromatic aldehydes in aqueous medium. Metal-free reaction condition, water as solvent, high bond forming efficiency (five new bonds formed in one step), good yields and easy purification process are the notable features of this methodology.
使用基于双功能硫脲的有机催化剂，通过2-羟基-1,4-萘醌、苯-1,2-二胺、丙二腈或其衍生物与异吲哚酮或芳香醛在水介质中的一锅四组分反应，合成了一系列吡喃并苯并菲嗪。无金属反应条件、以水为溶剂、高成键效率（一步形成五个新键）、高收率以及易于纯化的过程是该方法的显著特点。
