Nomura G S, Ashley D L, Pendergrast A H, Bernert J T, Patterson D G, Grainger J, Vanderveer D
Centers for Disease Control, Center for Environmental Health and Injury Control, Atlanta, GA 30333.
Food Chem Toxicol. 1989 Mar;27(3):165-71. doi: 10.1016/0278-6915(89)90065-3.
The compound 1-phenyl-5-vinylimidazolidine-2-thione was previously reported to be the causative agent in the outbreak referred to as Spanish toxic oil syndrome. X-ray crystallography, together with nuclear magnetic resonance and infra-red spectroscopy, now show the correct structure of this compound to be N-(5-vinyl-1,3-thiazolidin-2-ylidene)phenylamine (5-VTPA). Data for the structural characterization of 5-VTPA and the closely related isomer N-(4-vinyl-1,3-thiazolidin-2-ylidene)phenylamine are reported.
化合物1-苯基-5-乙烯基咪唑烷-2-硫酮先前被报道为所谓西班牙有毒油综合征疫情的致病因子。现在，X射线晶体学结合核磁共振和红外光谱表明，该化合物的正确结构为N-（5-乙烯基-1,3-噻唑烷-2-亚基）苯胺（5-VTPA）。本文报道了5-VTPA及其紧密相关异构体N-（4-乙烯基-1,3-噻唑烷-2-亚基）苯胺的结构表征数据。
