Kammüller M E, Verhaar H J, Versluis C, Terlouw J K, Brandsma L, Penninks A H, Seinen W
Department of Veterinary Pharmacology, University of Utrecht, The Netherlands.
Food Chem Toxicol. 1988 Feb;26(2):119-27. doi: 10.1016/0278-6915(88)90108-1.
A method is described for the synthesis and characterization of N-(2-hydroxy-3-butenyl)-N'-phenylthiourea, and its cyclization product, 1-phenyl-5-vinyl-2-imidazolidinethione (PVIZT). Fourteen coded oil samples associated with toxic oil syndrome cases in Spain were examined by gas chromatography-electron impact mass spectrometry for the presence of PVIZT. Although these samples were obtained from households where cases of toxic oil syndrome had been recorded, they differed extremely with regard to their anilide and sulphur contents. In one sample PVIZT was detected at an estimated concentration of 1 mg/kg.
本文描述了一种合成和表征N-(2-羟基-3-丁烯基)-N'-苯基硫脲及其环化产物1-苯基-5-乙烯基-2-咪唑烷硫酮（PVIZT）的方法。采用气相色谱-电子轰击质谱法对与西班牙有毒油综合征病例相关的14个编码油样进行检测，以确定是否存在PVIZT。尽管这些样品取自记录有毒油综合征病例的家庭，但它们的酰苯胺和硫含量差异极大。在一个样品中检测到PVIZT，估计浓度为1毫克/千克。
