Chung Chih-Ping, Chou Kun-Hsien, Chen Wei-Ta, Liu Li-Kuo, Lee Wei-Ju, Chen Liang-Kung, Lin Ching-Po, Wang Pei-Ning
Department of Neurology, School of Medicine, National Yang Ming University, Taipei, Taiwan; Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.
Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan; Brain Research Center, National Yang Ming University, Taipei, Taiwan.
Neurobiol Aging. 2016 Aug;44:143-150. doi: 10.1016/j.neurobiolaging.2016.04.025. Epub 2016 May 13.
The present study aimed to evaluate whether cerebral microbleeds (CMBs), as a presentation of cerebral small vessel diseases (CSVDs), are associated with physical frailty. This is a cross-sectional evaluation in participants from a community-based study, the I-Lan Longitudinal Aging Study. The physical frail status was evaluated using the Cardiovascular Health Study score, which includes components of weakness, low physical activity, slowness, exhaustion, and weight loss. The CMBs were assessed with magnetic resonance imaging using susceptibility-weighted imaging. Of the 962 subjects (62.5 [8.6] years, 44.2% men) included, 33.2% had physical prefrail and 3.3% had frail status. Compared with the robust subjects, prefrail and/or frail subjects presented with more overall CMB numbers and a higher number and/or incidence of CMB in the deep and/or infratentorial regions. Multivariate analysis with adjustment for age, sex, and vascular risk factors revealed that the CMB numbers were significantly associated with physical frailty. The brainstem was the only CMB location significantly associated with physical frailty (odds ratio, 95% CI, 13.50, 1.23-147.79) and the weakness component (5.04, 1.47-17.2), independent of age, sex, vascular risk factors, and the other presentations of CSVDs. Our results suggest that CSVD is involved in the pathophysiology of physical frailty.
本研究旨在评估作为脑小血管疾病（CSVD）表现形式的脑微出血（CMB）是否与身体虚弱相关。这是一项对来自基于社区的研究——宜兰纵向衰老研究的参与者进行的横断面评估。使用心血管健康研究评分评估身体虚弱状态，该评分包括虚弱、低体力活动、行动迟缓、疲惫和体重减轻等组成部分。使用磁敏感加权成像的磁共振成像评估CMB。在纳入的962名受试者（年龄62.5[8.6]岁，男性占44.2%）中，33.2%有身体虚弱前期表现，3.3%有虚弱状态。与身体强壮的受试者相比，虚弱前期和/或虚弱的受试者总体CMB数量更多，深部和/或幕下区域的CMB数量和/或发生率更高。在对年龄、性别和血管危险因素进行调整的多变量分析中，发现CMB数量与身体虚弱显著相关。脑干是唯一与身体虚弱显著相关的CMB部位（优势比，95%置信区间，13.50，1.23 - 147.79）以及与虚弱组成部分相关（5.04，1.47 - 17.2），独立于年龄、性别、血管危险因素和CSVD的其他表现。我们的结果表明，CSVD参与了身体虚弱的病理生理过程。
