Sut Stefania, Baldan Valeria, Faggian Marta, Peron Gregorio, Dall Acqua Stefano
University of Padova - Pharmaceutical and Pharmacological Sciences, Padova, Italy.
Curr Med Chem. 2016;23(28):3198-3223. doi: 10.2174/0929867323666160615104837.
"Nutraceuticals" are food-derived products largely used for their presumed healthpromoting or disease-preventing effects. In the recent years, many efforts have been aimed at assessing nutraceutical efficacy and safety, but these factors are difficult to address because of the complex chemical compositions and multiple mode of actions. Thus, the study of nutraceutical ingredients poses several challenges for the medicinal chemistry field, some of which are related to extraction and chemical characterization, some to in vitro and in vivo bioactivity evaluation, and some to the bioavailability and interaction of these natural mixtures with organs and microbiota. Furthermore, because of their nature as medicinal and food products, these nutraceuticals can also be considered as a valuable source of new "lead compounds", creating the opportunity to discover new classes of therapeutic agents. This review provides information on these themes, showing the new challenges that comprehensive medicinal chemistry research is called to answer in the field of nutraceuticals.
“营养保健品”是主要因其假定的促进健康或预防疾病作用而被大量使用的食品衍生产品。近年来，人们做出了许多努力来评估营养保健品的功效和安全性，但由于其化学成分复杂且作用方式多样，这些因素难以解决。因此，营养保健品成分的研究给药物化学领域带来了诸多挑战，其中一些与提取和化学表征有关，一些与体外和体内生物活性评估有关，还有一些与这些天然混合物的生物利用度以及它们与器官和微生物群的相互作用有关。此外，由于这些营养保健品兼具药品和食品的性质，它们也可被视为新“先导化合物”的宝贵来源，从而创造了发现新型治疗药物的机会。本综述提供了关于这些主题的信息，展示了全面的药物化学研究在营养保健品领域需要应对的新挑战。
