MacDermott R P, Nash G S, Nahm M H
Department of Medicine, Washington University Medical School, St. Louis, Missouri.
Immunol Invest. 1989 Jan-May;18(1-4):449-57. doi: 10.3109/08820138909112255.
Inflammatory bowel disease (IBD) intestinal mononuclear cells (MNC) exhibit decreased spontaneous IgA secretion with an increased percentage of monomeric IgA and IgA subclass 1 in both ulcerative colitis and Crohn's disease patients. When compared with control intestinal MNC, a marked increase in spontaneous secretion of IgG is observed from IBD MNC. The greatest increase in spontaneous IgG secretion is seen with ulcerative colitis intestinal MNC, due to the secretion of large amounts of IgG subclass 1. Crohn's disease intestinal MNC have increased IgG subclass 2 secretion. Similar differences in IgG subclass concentrations also occur in the sera of active, untreated, IBD patients. Therefore, major alterations occur with regard to spontaneous antibody secretion of IgA and IgG subclasses in IBD. Because intestinal MNC comprise a unique immunologic compartment, it will be important to better understand the regulatory mechanisms, effector capabilities, and inducing antigens involved in intestinal IgA and IgG subclass secretion in IBD.
炎症性肠病（IBD）患者的肠道单核细胞（MNC）在溃疡性结肠炎和克罗恩病患者中均表现出自发性IgA分泌减少，单体IgA和IgA亚类1的百分比增加。与对照肠道MNC相比，IBD MNC的IgG自发分泌显著增加。溃疡性结肠炎肠道MNC的自发IgG分泌增加最为明显，这是由于大量IgG亚类1的分泌。克罗恩病肠道MNC的IgG亚类2分泌增加。在未经治疗的活动性IBD患者血清中，IgG亚类浓度也存在类似差异。因此，IBD患者在IgA和IgG亚类的自发抗体分泌方面发生了重大改变。由于肠道MNC构成了一个独特的免疫区室，更好地了解IBD中肠道IgA和IgG亚类分泌所涉及的调节机制、效应能力和诱导抗原将非常重要。
