Wu K C, Mahida Y R, Priddle J D, Jewell D P
Gastroenterology Unit, Radcliffe Infirmary, Oxford, England.
Clin Exp Immunol. 1989 Oct;78(1):37-41.
We studied immunoglobulin production by isolated intestinal mononuclear cells from 25 patients with active inflammatory bowel disease (IBD) and 17 controls undergoing surgical resections for intestinal tumour or other disorders. Normal ileal intestinal mononuclear cells spontaneously produced greater amounts of IgA and IgM than did normal colon cells. In cells from patients with IBD there was a significantly reduced IgA production, but production of IgG was enhanced in both colon and ileum. The alteration in IgA and IgG production in IBD was confirmed by comparing the immunoglobulin production by mononuclear cells from inflamed with that from non-inflamed areas of mucosa in six patients with distal ulcerative colitis. The proportion of IgA-containing cells in isolated intestinal mononuclear cells from IBD mucosa was less than normal. However, the proportion of IgG-containing cells from IBD mucosa was not increased in isolated intestinal mononuclear cells although they produced more IgG than normal mucosal cells. Our study showed an altered pattern of immunoglobulin production by intestinal mononuclear cells isolated from patients with inflammatory bowel disease.
我们研究了25例活动性炎症性肠病（IBD）患者及17例因肠道肿瘤或其他疾病接受手术切除的对照者的分离肠单核细胞的免疫球蛋白产生情况。正常回肠肠单核细胞比正常结肠细胞自发产生更多的IgA和IgM。IBD患者的细胞中，IgA产生显著减少，但结肠和回肠中IgG的产生均增强。通过比较6例远端溃疡性结肠炎患者炎症黏膜与非炎症黏膜的单核细胞免疫球蛋白产生情况，证实了IBD中IgA和IgG产生的改变。IBD黏膜分离的肠单核细胞中含IgA细胞的比例低于正常。然而，IBD黏膜分离的肠单核细胞中含IgG细胞比例并未增加，尽管它们产生的IgG比正常黏膜细胞多。我们的研究显示，炎症性肠病患者分离的肠单核细胞免疫球蛋白产生模式发生了改变。
