Huang Guo-Xiang, Ji Xun-Ming, Ding Yu-Chuan, Huang Huai-Yu
a Department of Neurology , Xuanwu Hospital, Capital Medical University , Beijing , China.
b Department of Neurology , Second Affiliated Hospital of Nantong University , Nantong , China.
Neurol Res. 2016 Jun;38(6):518-23. doi: 10.1080/01616412.2016.1187825.
We sought to investigate whether serum cystatin C levels are correlated with either stroke severity or with potential risk factors of acute ischemic stroke.
171 patients with acute ischemic stroke and 99 control subjects with minor, unrelated diseases with stroke were included in this retrospective study. Serum cystatin C levels were determined in all subjects. Serum concentrations of several vascular risk factors in stoke patients were determined by biochemical assays. The severity of strokes was scored via the National Institutes of Health Stroke Scale (NIHSS).
Serum cystatin C levels were significantly increased in patients with acute ischemic stroke compared with control subjects (1.26 ± 0.34 mg/L vs. 0.78 ± 0.24 mg/L, p < 0.001).When analyzed in quartiles of serum cystatin C levels, concentrations were low (<0.75 mM) for 5 stroke patients (2.92%), intermediate (0.75-1 mM) for 42 patients (24.56%), high (1-1.25 mM) for 45 patients (26.32%), and very high (>1.25 mM) for 79 patients (46.20%). However, serum cystatin C levels were not correlated with NIHSS scores, serum total cholesterol, high-density lipoprotein, low-density lipoprotein, apolipoprotein a, or apolipoprotein b levels. Further, serum cystatin C concentrations in stroke patients were not correlated with the presence of intracranial arterial stenosis, hypertension, or diabetes.
Our study suggests that there is a close relationship between cystatin C and acute ischemic stroke, independently of conventional risk factors. But the levels of cystatin C are not correlated with the stroke severity.
我们试图研究血清胱抑素C水平是否与中风严重程度或急性缺血性中风的潜在危险因素相关。
本回顾性研究纳入了171例急性缺血性中风患者和99例患有轻微、与中风无关疾病的对照受试者。测定了所有受试者的血清胱抑素C水平。通过生化检测确定中风患者几种血管危险因素的血清浓度。采用美国国立卫生研究院卒中量表（NIHSS）对中风严重程度进行评分。
与对照受试者相比，急性缺血性中风患者的血清胱抑素C水平显著升高（1.26±0.34mg/L对0.78±0.24mg/L，p<0.001）。按血清胱抑素C水平四分位数分析时，5例中风患者（2.92%）的浓度较低（<0.75mM），42例患者（24.56%）为中等（0.75-1mM），45例患者（26.32%）为高（1-1.25mM），79例患者（46.20%）为非常高（>1.25mM）。然而，血清胱抑素C水平与NIHSS评分、血清总胆固醇、高密度脂蛋白、低密度脂蛋白、载脂蛋白a或载脂蛋白b水平无关。此外，中风患者的血清胱抑素C浓度与颅内动脉狭窄、高血压或糖尿病的存在无关。
我们的研究表明，胱抑素C与急性缺血性中风之间存在密切关系，独立于传统危险因素。但胱抑素C水平与中风严重程度无关。
