Department of Neurology, The Affiliated Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, China.
J Neurol. 2012 Oct;259(10):2053-9. doi: 10.1007/s00415-012-6453-2. Epub 2012 Feb 18.
Studies have indicated that serum levels of cystatin C (a sensitive marker of renal function) are significantly associated with cerebral vascular events. However, the influence of cystatin C on infarct size and hemorrhage volume in acute cerebral stroke has not been well established. A total of 222 patients with cerebral infarction, and 69 patients with cerebral hemorrhage, as well as 122 healthy controls were included in this study. Patients were further divided into subgroups according to infarct size and hemorrhage volume. Serum levels of cystatin C were significantly higher in cerebral-stroke patients than healthy controls (p < 0.05). Logistic multiple regression analyses showed that cystatin C levels were correlated with ischemic stroke and hemorrhagic cerebral stroke (p < 0.01). Cystatin C levels were correlated only with age, urea level, and creatinine level (p < 0.05). There was no correlation between cystatin C levels and systolic blood pressure, diastolic blood pressure, as well as levels of fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (p > 0.05). Patients with larger infarcts or larger hemorrhage volumes had higher levels of cystatin C (p < 0.05). Certain factors affect cystatin C levels in cerebral-stroke patients, and they could be considered to be independent predictors of infarct size and hemorrhage volume in acute cerebral stroke events.
研究表明，血清胱抑素 C（肾功能的敏感标志物）水平与脑血管事件显著相关。然而，胱抑素 C 对急性脑卒中性梗死体积和出血体积的影响尚未得到很好的证实。本研究共纳入 222 例脑梗死患者、69 例脑出血患者和 122 例健康对照者。根据梗死体积和出血体积将患者进一步分为亚组。脑卒中患者的血清胱抑素 C 水平明显高于健康对照组（p<0.05）。Logistic 多因素回归分析显示，胱抑素 C 水平与缺血性卒中和出血性脑卒中相关（p<0.01）。胱抑素 C 水平仅与年龄、尿素水平和肌酐水平相关（p<0.05）。胱抑素 C 水平与收缩压、舒张压以及空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平均无相关性（p>0.05）。梗死体积较大或出血体积较大的患者，胱抑素 C 水平较高（p<0.05）。某些因素影响脑卒中患者的胱抑素 C 水平，其可能是急性脑卒中事件中梗死体积和出血体积的独立预测因子。
