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[主动脉根部重建手术]

[Reconstructive surgery of the aortic root].

作者信息

Graeter T, Kindermann M, Fries R, Schäfers H J

机构信息

Abteilung für Thorax- und Herz-Gefäßchirurgie, Universitätskliniken des Saarlandes, D-66421 Homburg/Saar, Germany.

Abteilung für Kardiologie, Universitätskliniken des Saarlandes, D-66421 Homburg/Saar, Germany.

出版信息

Z Kardiol. 2000 Oct;89(Suppl 7):107-11. doi: 10.1007/PL00022879.

Abstract

Surgical treatment of proximal aortic disease traditionally consists of composite replacement of valve and aorta. Recent reconstructive procedures on the aortic root allow for treatment of aortic dilatation and concomitant aortic valve regurgitation without the associated disadvanteages of mechanical heart valves.From 10/95 to 09/99 we treated 84 patients for regurtitation of the aortic valve and dilatation of the aortic root. Valve preserving replacement of the root consisted of root remodeling (n = 68) or reimplantation of the aortic valve (n = 16). Operative mortality in valve-preserving surgery was not elevated compared to overall reults of proximal aortic replacement (3.6% vs 5.6%); this applied to elective procedures (1.8% vs 2.3%) as well as emergency operations (9.3% vs 16.3%). Initial aortic valve function was adequate in all cases. Actuarial freedom from regurgitation grade II or higher was 98% after root remodeling and 92% after valve reimplantation. Freedom from reoperation at two years was 96% in remodeling and 100% in valve reimplantation.Hemodynamic function of the reconstructed valve was investigated in 17 patients under conditions of rest and exercise. These were compared to 9 patients with a mechanical composite valve. Patients with reconstructed valves had almost physiologic gradients during rest and exercise. These gradients were thus significantly lower than the increased gradients of patients after composite replacement.Application of reconstructive procedures to the aortic root allows for restoration of aortic valve function in the majority of patients. Disadvantages of heart valve prostheses can be avoided, and the hemodynamic performance of the reconstructed valve appears almost physiologic.

摘要

近端主动脉疾病的外科治疗传统上包括瓣膜和主动脉的复合置换。最近对主动脉根部进行的重建手术能够治疗主动脉扩张和伴发的主动脉瓣反流,且不存在机械心脏瓣膜相关的缺点。从1995年10月至1999年9月,我们治疗了84例主动脉瓣反流和主动脉根部扩张的患者。保留瓣膜的根部置换包括根部重塑(n = 68)或主动脉瓣再植入(n = 16)。与近端主动脉置换的总体结果相比,保留瓣膜手术的手术死亡率并未升高(3.6%对5.6%);这适用于择期手术(1.8%对2.3%)以及急诊手术(9.3%对16.3%)。所有病例术后早期主动脉瓣功能均良好。根部重塑术后无Ⅱ级或更高程度反流的精算生存率为98%,瓣膜再植入术后为92%。根部重塑术后两年免于再次手术的生存率为96%,瓣膜再植入术后为100%。对17例患者在静息和运动状态下研究了重建瓣膜的血流动力学功能,并与9例植入机械复合瓣膜的患者进行了比较。重建瓣膜的患者在静息和运动时的压力阶差几乎接近生理状态。因此,这些压力阶差显著低于复合置换术后患者升高的压力阶差。对主动脉根部应用重建手术能够使大多数患者的主动脉瓣功能得以恢复。心脏瓣膜假体的缺点得以避免,且重建瓣膜的血流动力学性能几乎接近生理状态。

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