miR-186 在人类癌症中的功能和作用机制。
Functions and mechanisms of miR-186 in human cancer.
机构信息
Department of Orthopedics, Taizhou Clinical Medical School of Nanjing Medical University (Taizhou People's Hospital), Taizhou, Jiangsu, China.
Department of Chemotherapy, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China.
出版信息
Biomed Pharmacother. 2019 Nov;119:109428. doi: 10.1016/j.biopha.2019.109428. Epub 2019 Sep 13.
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Mounting evidence suggests the involvement of miRNAs in carcinogenesis and the development of human cancer. Among the miRNAs, miR-186 has been extensively studied in various cancers. The expression of miR-186 in tissues varies depending on the type of cancer and miR-186 in tissues and body fluids may serve as a marker for the diagnosis and prognosis of cancers. Various biological processes in human cancer are affected by miR-186. Additionally, miR-186 itself is regulated by several factors. Thus, this evidence highlights the potential value of miR-186 in the diagnosis, prognosis and treatment of human cancer.
微小 RNA（miRNAs）是一种小型非编码 RNA，可在转录后水平调控基因表达。越来越多的证据表明，miRNAs 参与了癌症的发生和人类癌症的发展。在众多 miRNAs 中，miR-186 在各种癌症中得到了广泛研究。miR-186 在组织中的表达因癌症类型而异，组织和体液中的 miR-186 可能作为癌症诊断和预后的标志物。miR-186 还可影响人类癌症中的多种生物学过程。此外，miR-186 本身也受到多种因素的调控。因此，这些证据突出了 miR-186 在人类癌症的诊断、预后和治疗中的潜在价值。
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