动物体内14C标记的FCE 22101的尿液代谢产物。

Urinary metabolites of 14C-labelled FCE 22101 in animals.

作者信息

Strolin Benedetti M, Battaglia R, Vicario G, Roncucci R

机构信息

Farmitalia Carlo Erba, Research and Development, Milan, Italy.

出版信息

J Antimicrob Chemother. 1989 Mar;23 Suppl C:173-7. doi: 10.1093/jac/23.suppl_c.173.

DOI:10.1093/jac/23.suppl_c.173

PMID:2732140

Abstract

The metabolism of 14C-FCE 22101 has been studied by radio-HPLC in the urine of various animal species. Five main chromatographic peaks were detected and named, in order of decreasing polarity, P, P1, X, UD (unchanged drug) and LP. P1 is the open beta-lactam ring metabolite obtained by the action of dehydropeptidase. The stability of FCE 22101 and P1 is pH-dependent, and differences between species in urinary metabolic patterns might therefore be partially explained by different urinary pH values.

摘要

已通过放射性高效液相色谱法在各种动物物种的尿液中研究了14C-FCE 22101的代谢情况。检测到五个主要色谱峰，并按极性递减顺序命名为P、P1、X、UD（未变化的药物）和LP。P1是通过脱氢肽酶作用获得的开环β-内酰胺环代谢物。FCE 22101和P1的稳定性取决于pH值，因此不同物种尿液代谢模式的差异可能部分由不同的尿液pH值来解释。