Jumeau R, Renard-Oldrini S, Courrech F, Buchheit I, Oldrini G, Vogin G, Peiffert D
Department of radiotherapy, institut de cancérologie de Lorraine, 6, avenue de Bourgogne, 54500 Vandœuvre-lès-Nancy, France.
Department of radiotherapy, institut de cancérologie de Lorraine, 6, avenue de Bourgogne, 54500 Vandœuvre-lès-Nancy, France.
Cancer Radiother. 2016 Jul;20(5):341-6. doi: 10.1016/j.canrad.2016.03.008. Epub 2016 Jun 16.
Brachytherapy is a well-known treatment in the management of skin tumors. For facial or scalp lesions, applicators have been developed to deliver non-invasive treatment. We present cases treated with customized applicators with high dose rate system.
Patients with poor performance status treated for malignant skin lesions of the scalp or the facial skin between 2011 and 2014 were studied. Afterloading devices were chosen between Freiburg(®) Flap, silicone-mold or wax applicators. The clinical target volume (CTV) was created by adding margins to lesions (10mm to 20mm). The dose schedules were 25Gy in five fractions for postoperative lesions, 30Gy in six fractions for exclusive treatments and a single session of 8Gy could be considered for palliative treatments.
In 30 months, 11 patients received a treatment for a total of 12 lesions. The median age was 80 years. The median follow-up was 17 months and the 2-year local control rate was 91%. The mean CTV surface was 41.1cm(2) with a mean thickness of 6.1mm. We conceived three wax applicators, used our silicone-mold eight times and the Freiburg(®) Flap one time. We observed only low-grade radiodermitis (grade I: 50%, grade II: 33%), and no high-grade skin toxicity.
High dose rate brachytherapy with customized applicators for facial skin and scalp lesions is efficient and safe. It is a good modality to treat complex lesions in patients unfit for invasive treatment.
近距离放射治疗是皮肤肿瘤治疗中一种广为人知的方法。对于面部或头皮病变,已开发出用于进行非侵入性治疗的施源器。我们展示了使用高剂量率系统定制施源器治疗的病例。
对2011年至2014年间因头皮或面部皮肤恶性病变接受治疗且身体状况较差的患者进行研究。后装装置在弗莱堡(®)皮瓣、硅胶模具或蜡质施源器中选择。临床靶区(CTV)通过在病变周围添加边缘(10毫米至20毫米)来确定。术后病变的剂量方案为分五次给予25Gy,单纯治疗为分六次给予30Gy,姑息治疗可考虑单次给予8Gy。
在30个月内,11名患者共接受了12次针对12个病变的治疗。中位年龄为80岁。中位随访时间为17个月,2年局部控制率为91%。CTV平均表面积为41.1平方厘米,平均厚度为6.1毫米。我们制作了三个蜡质施源器,硅胶模具使用了八次,弗莱堡(®)皮瓣使用了一次。我们仅观察到低度放射性皮炎(I级:50%,II级:33%),未出现高度皮肤毒性。
使用定制施源器对面部皮肤和头皮病变进行高剂量率近距离放射治疗是有效且安全的。对于不适合侵入性治疗的患者,它是治疗复杂病变的一种良好方式。