接触高剂量率放射治疗（近距离放射疗法）治疗非黑色素瘤皮肤癌：单机构系列和文献复习。
Non-melanoma Skin Cancer Treated by Contact High-dose-rate Radiotherapy (Brachytherapy): A Mono-institutional Series and Literature Review.
机构信息
U.O.C. Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Istituto di Radiologia, Università Cattolica del Sacro Cuore, Rome, Italy.
出版信息
In Vivo. 2021 Jul-Aug;35(4):2313-2319. doi: 10.21873/invivo.12505.
BACKGROUND/AIM: Non-melanoma skin cancers (NMSC) are the most common neoplasms worldwide and their incidence has been proven to increase in recent years and their treatment should aim at cancer cure as well as cosmetic and functional results. The aim of the study was to report the results of our mono-institutional series of high-dose-rate radiotherapy (cHDR-RT) in NMSC, based on a homogenous technique and two different treatment schedules.
PATIENTS AND METHODS
All patients affected by NMSC who were consecutively evaluated and treated at our Interventional Oncology Center from October 2018 to August 2020, were included. Patients underwent cHDR-RT using flap applicators and remotely afterloaded Ir-192 sources.
RESULTS
Overall, 51 patients were treated for a total of 67 lesions. Local control (LC) and disease-specific survival (DSS) were 94.0% and 100%, respectively. Grade 1, grade 2, grade 3 and grade 4 acute toxicity rates were 24.6%, 3.5%, 3.5%, and 0.0%, respectively. The cosmetic results were graded as excellent/good, fair, and poor in 73.7%, 19.3%, and 7.0%.
CONCLUSION
cHDR-RT of NMSC is an effective alternative to surgery due to excellent outcomes both in terms of local control and aesthetic results especially in the face.
背景/目的：非黑色素瘤皮肤癌（NMSC）是全球最常见的肿瘤，其发病率近年来已被证明有所增加，其治疗应旨在实现癌症治愈以及美容和功能效果。本研究的目的是报告我们单机构高剂量率放疗（cHDR-RT）治疗 NMSC 的结果，该研究基于一种同质技术和两种不同的治疗方案。
患者和方法
所有在 2018 年 10 月至 2020 年 8 月期间在我们介入肿瘤学中心连续评估和治疗的 NMSC 患者均被纳入研究。患者采用 flaps 施源器和远程加载 Ir-192 源接受 cHDR-RT 治疗。
结果
总体而言，51 例患者共 67 个病灶接受治疗。局部控制（LC）和疾病特异性生存率（DSS）分别为 94.0%和 100%。急性毒性分级为 1 级、2 级、3 级和 4 级的比例分别为 24.6%、3.5%、3.5%和 0.0%。美容效果分级为优/好、中、差的比例分别为 73.7%、19.3%和 7.0%。
结论
cHDR-RT 治疗 NMSC 是手术的有效替代方法，因为它在局部控制和美容效果方面均有出色表现，尤其是在面部。
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