载脂蛋白Eε4不影响帕金森病患者的认知表现。
Apolipoprotein E ε4 does not affect cognitive performance in patients with Parkinson's disease.
作者信息
Mengel David, Dams Judith, Ziemek Jannis, Becker Julian, Balzer-Geldsetzer Monika, Hilker Rüdiger, Baudrexel Simon, Kalbe Elke, Schmidt Nele, Witt Karsten, Liepelt-Scarfone Inga, Gräber Susanne, Petrelli Annette, Neuser Petra, Schulte Claudia, Linse Katharina, Storch Alexander, Wittchen Hans-Ulrich, Riedel Oliver, Mollenhauer Brit, Ebentheuer Jens, Trenkwalder Claudia, Klockgether Thomas, Spottke Annika, Wüllner Ullrich, Schulz Jörg B, Reetz Kathrin, Heber Ines Ann, Ramirez Alfredo, Dodel Richard
机构信息
Department of Neurology, Philipps-University, Marburg, Germany.
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
出版信息
Parkinsonism Relat Disord. 2016 Aug;29:112-6. doi: 10.1016/j.parkreldis.2016.04.013. Epub 2016 Apr 19.
INTRODUCTION
Cognitive impairment is a common and disabling non-motor symptom in Parkinson's disease (PD). The apolipoprotein E (APOE) allele ε4 is a known risk factor for Alzheimer's disease and has also been suggested to be a risk factor for dementia in PD and even a predictor of impairment in certain cognitive domains.
METHODS
A total of 447 PD patients (PD patients without cognitive impairment: n = 187; PD patients with mild cognitive impairment: n = 188; PD patients with dementia: n = 72) were included from an ongoing observational German multicenter cohort study (LANDSCAPE study). All patients underwent an extensive neuropsychological test battery, including assessments of memory, visuospatial functioning, attention, language, and executive function. APOE genotype was determined by an allelic discrimination assay. Linear regression analysis was used to explore the associations between APOE-ε4 and cognitive performance.
RESULTS
The APOE-ε4 allele was not associated with a diagnosis of cognitive impairment in PD (PD with mild cognitive impairment and PD with dementia) or with deficits in specific neuropsychological domains in our study cohort.
CONCLUSION
Our data question the relevance of the APOE-ε4 allele as a predictor of cognitive impairment in PD.
引言
认知障碍是帕金森病（PD）常见且致残的非运动症状。载脂蛋白E（APOE）ε4等位基因是已知的阿尔茨海默病风险因素，也有人提出它是PD痴呆的风险因素，甚至是某些认知领域损害的预测指标。
方法
从一项正在进行的德国多中心观察性队列研究（LANDSCAPE研究）中纳入了447例PD患者（无认知障碍的PD患者：n = 187；轻度认知障碍的PD患者：n = 188；痴呆的PD患者：n = 72）。所有患者均接受了广泛的神经心理测试组，包括记忆、视觉空间功能、注意力、语言和执行功能评估。通过等位基因鉴别测定法确定APOE基因型。采用线性回归分析探讨APOE-ε4与认知表现之间的关联。
结果
在我们的研究队列中，APOE-ε4等位基因与PD（轻度认知障碍的PD和痴呆的PD）的认知障碍诊断或特定神经心理领域的缺陷无关。
结论
我们的数据质疑了APOE-ε4等位基因作为PD认知障碍预测指标的相关性。
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